Nucleocapsid protein function in early infection processes
JA Thomas, RJ Gorelick - Virus research, 2008 - Elsevier
The role of nucleocapsid protein (NC) in the early steps of retroviral replication appears
largely that of a facilitator for reverse transcription and integration. Using a wide variety of …
largely that of a facilitator for reverse transcription and integration. Using a wide variety of …
HIV type 1 Gag as a target for antiviral therapy
AA Waheed, EO Freed - AIDS research and human retroviruses, 2012 - liebertpub.com
The Gag proteins of HIV-1 are central players in virus particle assembly, release, and
maturation, and also function in the establishment of a productive infection. Despite their …
maturation, and also function in the establishment of a productive infection. Despite their …
Anisotropic, polarizable molecular mechanics studies of inter-and intramolecular interactions and ligand− macromolecule complexes. A bottom-up strategy
We present an overview of the SIBFA polarizable molecular mechanics procedure, which is
formulated and calibrated on the basis of quantum chemistry (QC). It embodies nonclassical …
formulated and calibrated on the basis of quantum chemistry (QC). It embodies nonclassical …
[HTML][HTML] Pan-retroviral nucleocapsid-mediated phase separation regulates genomic RNA positioning and trafficking
The duality of liquid-liquid phase separation (LLPS) of cellular components into
membraneless organelles defines the nucleation of both normal and disease processes …
membraneless organelles defines the nucleation of both normal and disease processes …
Zinc and copper ions differentially regulate prion-like phase separation dynamics of pan-virus nucleocapsid biomolecular condensates
A Monette, AJ Mouland - Viruses, 2020 - mdpi.com
Liquid-liquid phase separation (LLPS) is a rapidly growing research focus due to numerous
demonstrations that many cellular proteins phase-separate to form biomolecular …
demonstrations that many cellular proteins phase-separate to form biomolecular …
NCp7: Targeting a multitasking protein for next-generation anti-HIV drug development part 1: Covalent inhibitors
Highlights•NCp7 plays several roles in the viral life cycle.•Covalent NCp7 inhibitors are able
to extrude the zinc from the protein.•The SAR of covalent NCp7 inhibitors is discussed.•The …
to extrude the zinc from the protein.•The SAR of covalent NCp7 inhibitors is discussed.•The …
Nucleocapsid protein: a desirable target for future therapies against HIV-1
HIV reverse transcription and nucleocapsid. After the capsid has entered the cell, reverse
transcriptase (A) creates a DNA copy (green) of the HIV RNA genome (yellow), using a …
transcriptase (A) creates a DNA copy (green) of the HIV RNA genome (yellow), using a …
Nickel-Catalyzed ortho-CH Thiolation of N-Benzoyl α-Amino Acid Derivatives
We developed the first nickel-catalyzed direct ortho-thiolation of N-benzoyl α-amino acid
derivatives. This novel strategy showed wide generality, functional tolerance, and high …
derivatives. This novel strategy showed wide generality, functional tolerance, and high …
Targeting the viral nucleocapsid protein in anti-HIV-1 therapy
Y Mely, H Rocquigny, V Shvadchak… - Mini reviews in …, 2008 - benthamdirect.com
The nucleocapsid protein (NC) plays seminal roles in HIV replication, thus representing a
major drug target. NC functions rely on its two zinc-fingers and flanking basic residues. Zinc …
major drug target. NC functions rely on its two zinc-fingers and flanking basic residues. Zinc …
Comprehensive survey of combinatorial library synthesis: 2004
RE Dolle - Journal of combinatorial chemistry, 2005 - ACS Publications
Comprehensive Survey of Combinatorial Library Synthesis: 2004 | ACS Combinatorial Science
ACS ACS Publications C&EN CAS Find my institution Log In Journal of Combinatorial Chemistry …
ACS ACS Publications C&EN CAS Find my institution Log In Journal of Combinatorial Chemistry …