Brain activity during sleep is characterized by circuit-specific oscillations, including slow
waves, spindles and theta waves, which are nested in thalamocortical or hippocampal …

During recent years, the preclinical stage of Alzheimer's disease (AD) has become a major
focus of research. Continued failures in clinical trials and the realization that early …

Sleep is an essential process that supports learning and memory by acting on synapses
through poorly understood molecular mechanisms. Using biochemistry, proteomics, and …

A vast number of different neuronal activity patterns could each induce a different set of
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …

The brain is a massive neuronal network, organized into anatomically distributed sub-
circuits, with functionally relevant activity occurring at timescales ranging from milliseconds …

Homeostatic mechanisms stabilize neuronal activity in vivo, but whether this process gives
rise to balanced network dynamics is unknown. Here, we continuously monitored the …

Brain plasticity is dynamically regulated across the life span, peaking during windows of
early life. Typically assessed in the physiological range of milliseconds (real time), these …

During sleep, animals do not eat, reproduce or forage. Sleeping animals are vulnerable to
predation. Yet, the persistence of sleep despite evolutionary pressures, and the deleterious …

Alzheimer's disease (AD) starts from pure cognitive impairments and gradually progresses
into degeneration of specific brain circuits. Although numerous factors initiating AD have …

It has become widely accepted that homeostatic and Hebbian plasticity mechanisms work
hand in glove to refine neural circuit function. Nonetheless, our understanding of how these …