Next-generation sequencing technologies for helminth diagnostics and surveillance in ruminants: shifting diagnostic barriers

A Antonopoulos, JS Gilleard, J Charlier - Trends in Parasitology, 2024 - cell.com
Helminth infections in grazing ruminants are a major issue for livestock farming globally, but
are unavoidable in outdoor grazing systems and must be effectively managed to avoid …

[HTML][HTML] Structure activity relationship and target prediction for ABX464 analogues in Caenorhabditis elegans

HT Shanley, AC Taki, N Nguyen, T Wang… - Bioorganic & Medicinal …, 2024 - Elsevier
Global challenges with treatment failures and/or widespread resistance in parasitic worms
against commercially available anthelmintics lend impetus to the development of new …

[HTML][HTML] Comparative structure activity and target exploration of 1, 2-diphenylethynes in Haemonchus contortus and Caenorhabditis elegans

HT Shanley, AC Taki, N Nguyen, T Wang… - International Journal for …, 2024 - Elsevier
Infections and diseases caused by parasitic nematodes have a major adverse impact on the
health and productivity of animals and humans worldwide. The control of these parasites …

A novel class of insecticidal alkylsulfones are potent inhibitors of vesicular acetylcholine transport

J Goodchild, YJ Chen, J Blythe, LC Firth, E Hirst… - Pesticide Biochemistry …, 2024 - Elsevier
Pyridine alkylsulfone derivatives typified by oxazosulfyl (Sumitomo Chemical Company Ltd.)
and compound A2 (Syngenta) represent a new class of insecticides, with potent activity …

Mapping resistance-associated anthelmintic interactions in the model nematode Caenorhabditis elegans

EG Rehborg, NJ Wheeler… - PLOS Neglected Tropical …, 2023 - journals.plos.org
Parasitic nematodes infect billions of people and are mainly controlled by anthelmintic mass
drug administration (MDA). While there are growing efforts to better understand mechanisms …

Novel Approaches for Anthelmintic and Nematicide Discovery

J Knox - 2024 - tspace.library.utoronto.ca
Parasitic nematodes place an enormous burden on humanity. Nematodes infect over one
quarter of the world's population and cause billions of dollars in livestock and plant crop …