DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to
the broader group of cellular DExD/H helicases. Members of the DEAD-box helicase family …

Once thought a mere ribosome factory, the nucleolus has been viewed in recent years as an
extremely sensitive gauge of diverse cellular stresses. Emerging concepts in nucleolar …

SARS-CoV-2 genomic and subgenomic RNA (sgRNA) transcripts hijack the host cell's
machinery. Subcellular localization of its viral RNA could, thus, play important roles in viral …

Nucleoli are multicomponent condensates defined by coexisting sub-phases. We identified
distinct intrinsically disordered regions (IDRs), including acidic (D/E) tracts and K-blocks …

Viruses have often evolved overlapping reading frames in order to maximize their coding
capacity. Until recently, the segmented dsRNA genome of viruses of the Orbivirus genus …

Zika virus (ZIKV) infection of neural progenitor cells (NPCs) in utero is associated with
neurological disorders, such as microcephaly, but a detailed molecular understanding of …

Due to their exceptional simplicity of organization, viruses rely on the resources, molecular
mechanisms, macromolecular complexes, regulatory pathways, and functional …

Host-oriented antiviral therapeutics are promising treatment options to combat COVID-19
and its emerging variants. However, relatively little is known about the cellular proteins …

We report here that in rat and human neuroprogenitor cells as well as rat embryonic cortical
neurons Zika virus (ZIKV) infection leads to ribosomal stress that is characterized by …

Host-influenza virus interplay at the transcript level has been extensively characterized in
epithelial cells. Yet, there are no studies that simultaneously characterize human host and …