Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies
The fight against coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection is
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …
still raging. However, the pathophysiology of acute and post-acute manifestations of COVID …
Adverse effects of COVID-19 mRNA vaccines: the spike hypothesis
Vaccination is a major tool for mitigating the coronavirus disease 2019 (COVID-19)
pandemic, and mRNA vaccines are central to the ongoing vaccination campaign that is …
pandemic, and mRNA vaccines are central to the ongoing vaccination campaign that is …
Persistent circulation of soluble and extracellular vesicle‐linked Spike protein in individuals with postacute sequelae of COVID‐19
V Craddock, A Mahajan, L Spikes… - Journal of medical …, 2023 - Wiley Online Library
ABSTRACT SARS‐CoV‐2, the causative agent of COVID‐19 disease, has resulted in the
death of millions worldwide since the beginning of the pandemic in December 2019. While …
death of millions worldwide since the beginning of the pandemic in December 2019. While …
SARS-CoV-2 spike protein 1 activates microvascular endothelial cells and complement system leading to platelet aggregation
Microvascular thrombosis is associated with multiorgan failure and mortality in coronavirus
disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability …
disease 2019 (COVID-19). Although thrombotic complications may be ascribed to the ability …
SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling
The spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can
interact with endothelial cells. However, no studies demonstrated the direct effect of the …
interact with endothelial cells. However, no studies demonstrated the direct effect of the …
SARS-CoV-2 and the spike protein in endotheliopathy
Abstract SARS-CoV-2, the causative agent of COVID-19, primarily affects the epithelial
compartment in the upper and lower airways. There is evidence that the microvasculature in …
compartment in the upper and lower airways. There is evidence that the microvasculature in …
COVID-19 mRNA vaccines: the molecular basis of some adverse events
G Giannotta, A Murrone, N Giannotta - Vaccines, 2023 - mdpi.com
Each injection of any known vaccine results in a strong expression of pro-inflammatory
cytokines. This is the result of the innate immune system activation, without which no …
cytokines. This is the result of the innate immune system activation, without which no …
A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets
Studying viral–host protein–protein interactions can facilitate the discovery of therapies for
viral infection. We use high-throughput yeast two-hybrid experiments and mass spectrometry …
viral infection. We use high-throughput yeast two-hybrid experiments and mass spectrometry …
Convergent evolution dynamics of SARS-CoV-2 and HIV surface envelope glycoproteins driven by host cell surface receptors and lipid rafts: lessons for the future
Although very different, in terms of their genomic organization, their enzymatic proteins, and
their structural proteins, HIV and SARS-CoV-2 have an extraordinary evolutionary potential …
their structural proteins, HIV and SARS-CoV-2 have an extraordinary evolutionary potential …
[HTML][HTML] Final results of a randomized, placebo-controlled, two-arm, parallel clinical trial of proxalutamide for hospitalized COVID-19 patients: a multiregional, joint …
FA Cadegiani, RA Zimerman, DN Fonseca, MN Correia… - Cureus, 2021 - ncbi.nlm.nih.gov
Background The role of androgens on COVID-19 is well established. Proxalutamide is a
second-generation, non-steroidal antiandrogen (NSAA) with the highest antiandrogen …
second-generation, non-steroidal antiandrogen (NSAA) with the highest antiandrogen …