Drug-induced photosensitivity: Photoallergic and phototoxic reactions

AF Monteiro, M Rato, C Martins - Clinics in dermatology, 2016 - Elsevier
Drug-induced photosensitivity refers to the development of cutaneous disease due to the
interaction between a given chemical agent and sunlight. Photosensitivity reactions can be …

Drug-induced photosensitivity—an update: culprit drugs, prevention and management

KM Blakely, AM Drucker, CF Rosen - Drug safety, 2019 - Springer
Photosensitive drug eruptions are cutaneous adverse events due to exposure to a
medication and either ultraviolet or visible radiation. In this review, the diagnosis, prevention …

Drug-induced photosensitivity—from light and chemistry to biological reactions and clinical symptoms

J Kowalska, J Rok, Z Rzepka, D Wrześniok - Pharmaceuticals, 2021 - mdpi.com
Photosensitivity is one of the most common cutaneous adverse drug reactions. There are
two types of drug-induced photosensitivity: photoallergy and phototoxicity. Currently, the …

Phototoxicity─ Medicinal Chemistry Strategies for Risk Mitigation in Drug Discovery

TJ Harrison, X Chen, K Yasoshima… - Journal of Medicinal …, 2023 - ACS Publications
Phototoxicity is a common safety concern encountered by project teams in pharmaceutical
research and has the potential to stop progression of an otherwise promising candidate …

[HTML][HTML] Association between the use of thiazide diuretics and the risk of skin cancers: a meta-analysis of observational studies

D Shin, ES Lee, J Kim, L Guerra, D Naik… - Journal of clinical …, 2019 - ncbi.nlm.nih.gov
Background Thiazide diuretics are among the most widely prescribed antihypertensive
agents. Given their photosensitizing effects, however, there are concerns that they may …

[HTML][HTML] The phenomenon of phototoxicity and long-term risks of commonly prescribed and structurally diverse drugs

AE Davis, GE Kennelley, T Amaye-Obu… - … of photochemistry and …, 2024 - Elsevier
Photosensitivity to structurally diverse drugs is a common but under-reported adverse
cutaneous reaction and can be classified as phototoxic or photoallergic. Phototoxic …

Risk of nonmelanoma skin cancer in association with use of hydrochlorothiazide-containing products in the United States

E Eworuke, N Haug, M Bradley… - JNCI Cancer …, 2021 - academic.oup.com
Background European studies reported an increased risk of nonmelanoma skin cancer
associated with hydrochlorothiazide (HCTZ)-containing products. We examined the risks of …

Onco-hypertension: an emerging specialty

P Gudsoorkar, R Ruf, H Adnani, K Safdar… - Advances in Chronic …, 2021 - Elsevier
Cancer is one of the leading causes of death worldwide. With the introduction of newer
chemotherapeutic agents, targeted therapies, and immunotherapy, the prognosis and …

Hydrochlorothiazide use and risk of nonmelanoma skin cancers: a biological plausibility study

E Bigagli, L Cinci, M D'Ambrosio… - Oxidative Medicine …, 2021 - Wiley Online Library
Recent studies reported the association between increased risk of nonmelanoma skin
cancers (NMSCs) and the use of hydrochlorothiazide (HCTZ), one of the most commonly …

Latest evidence regarding the effects of photosensitive drugs on the skin: pathogenetic mechanisms and clinical manifestations

F Lozzi, C Di Raimondo, C Lanna, L Diluvio, S Mazzilli… - Pharmaceutics, 2020 - mdpi.com
Photosensitivity induced by drugs is a widely experienced problem, concerning both
molecule design and clinical practice. Indeed, photo-induced cutaneous eruptions represent …