The activation of a substrate by a chiral catalyst is now regarded as one of the most powerful
strategies that can be employed in the art of asymmetric synthesis. 1 The development of …

This Review examines recent developments in late transition metal-catalyzed
hydroamination and-amidation reactions. A hydroamination is a reaction in which an N− H …

To increase the reliability and success rate of drug discovery, efforts have been made to
increase the C (sp 3) fraction and avoid flat molecules. sp 3-Rich enantiopure amines are …

Low molecular weight synthetic peptides have been demonstrated to be effective catalysts
for an increasingly wide array of asymmetric transformations. In many cases, these peptide …

Asymmetric reductive amination (ARA) of a prochiral carbonyl compound with an amine
using a H2/hydrogen surrogate is a concise and operationally simple method for the …

The nature of the excited state renders the development of chiral catalysts for
enantioselective photochemical reactions a considerable challenge. The absorption of a …

The structural complexity of glycans poses a serious challenge in the chemical synthesis of
glycosides, oligosaccharides and glycoconjugates. Glycan complexity, determined by …

Charged intermediates and reagents are ubiquitous in organic transformations. The
interaction of these ionic species with chiral neutral, anionic, or cationic small molecules has …

This review highlights a number of additives that can be used to make asymmetric reactions
perfect. Without changing other reaction conditions, simply adding additives can lead to …

The first highly enantioselective catalytic protocol for the reductive coupling of ketones and
hydrazones is reported. These reactions proceed through neutral ketyl radical intermediates …