Amyotrophic lateral sclerosis (ALS) is an intractable disease that causes respiratory failure
leading to mortality. The main locus of ALS is motor neurons. The success of antisense …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
degeneration of motor neurons in the brain and spinal cord. The causes of ALS are not fully …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk
of one in 350 people and an unmet need for disease-modifying therapies. We conducted a …

Amyotrophic lateral sclerosis (ALS) is a complex disease that leads to motor neuron death.
Despite heritability estimates of 52%, genome-wide association studies (GWASs) have …

Human cells are exposed to numerous exogenous and endogenous insults every day.
Unlike other molecules, DNA cannot be replaced by resynthesis, hence damage to DNA can …

Emerging studies reveal that neurodegenerative disorders, including amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD), are commonly linked to DNA damage …

Intraflagellar transport (IFT) is a microtubule-based system that supports the assembly and
maintenance of cilia. The dysfunction of IFT leads to ciliopathies of variable severity. Two of …

The NEK1 kinase controls ciliogenesis, mitosis, and DNA repair, and NEK1 mutations cause
human diseases including axial spondylometaphyseal dysplasia and amyotrophic lateral …

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease leading to
motor neuron loss. Currently mutations in> 40 genes have been linked to ALS, but the …

Neurodegenerative diseases are one of the greatest medical burdens of the modern age,
being mostly incurable and with limited prognostic and diagnostic tools. Amyotrophic lateral …