Depressive disorders (DDs) are one of the most widespread forms of psychiatric pathology.
According to the World Health Organization, about 350 million people in the world are …

Major depressive disorder (MDD) is a global problem for which current pharmacotherapies
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …

The hypothalamic–pituitary–adrenal (HPA) axis has been implicated in the pathophysiology
of a variety of mood and cognitive disorders. Neuroendocrine studies have demonstrated …

Intestinal microbes are an important system in the human body, with significant effects on
behavior. An increasing body of research indicates that intestinal microbes affect brain …

A concatenation of findings from preclinical and clinical studies support a preeminent
function for the corticotropin-releasing factor (CRF) system in mediating the physiological …

Vitamins are dietary components which are necessary for life. They play a major role in
health and their deficiency may be linked to symptoms of psychiatric disorders. B vitamins …

Major depressive disorder (MDD) is a stress-related mental disorder with a lifetime
prevalence of 20% and, thus, is one of the most prevalent mental health disorders …

Increasing evidence indicates that there are various interactions between the nervous
system and the immune system, and that the immune system plays an important role in the …

Nowadays depression is considered as a systemic illness with different biological
mechanisms involved in its etiology, including inflammatory response, hypothalamic …

Methyl donors such as choline, betaine, folic acid, methionine, and vitamins B6 and B12 are
critical players in the one-carbon metabolism and have neuroprotective functions. The one …