The discovery of steroid hormone receptors in brain regions that mediate every aspect of
brain function has broadened the definition of 'neuroendocrinology'to include the reciprocal …

The mineralocorticoid receptor (MR) was originally identified as a regulator of blood
pressure, able to modulate renal sodium handling in response to its principal ligand …

Since the mineralocorticoid receptor (MR) was cloned 30 years ago, it has become clear that
MR is expressed in extra-renal tissues, including the cardiovascular system, where it is …

The effects of the renin–angiotensin system (RAS) surpass the renal and cardiovascular
systems to encompass other body tissues and organs, including the brain. Angiotensin II …

Objective: to investigate the relationship between the use of spironolactone and the risk of
stroke in hypertensive patients. Methods: a total of 2464 spironolactone users and 12,928 …

Atherosclerosis is a chronic inflammatory disease of the vasculature that causes significant
morbidity and mortality from myocardial infarction, stroke, and peripheral vascular disease …

Aldosterone binds to mineralocorticoid receptors (MRs) on renal epithelial cells to regulate
sodium and water reabsorption, and therefore blood pressure. Recently, the actions of …

Objective: In a model of secondary hypertension, mineralocorticoid receptor (MR)
antagonism during the development of hypertension prevents the impairment of transient …

Calcium/voltage-activated potassium channels (BK) control smooth muscle (SM) tone and
cerebral artery diameter. They include channel-forming α and regulatory β1 subunits, the …

Spironolactone, a potassium-sparing diuretic and aldosterone antagonist, is a
mineralocorticoid hormone commonly prescribed to patients suffering from heart failure …