Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Mitochondria play key roles in bioenergetics, metabolism, and signaling; therefore, stable
mitochondrial function is essential for cell survival, particularly in energy-intensive neuronal …

Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …

Autophagy is a delicate intracellular degradation process that occurs due to diverse stressful
conditions, including the accumulation of damaged proteins and organelles as well as …

ER-mitochondrial contact sites (EMCSs) are important for mitochondrial function. Here, we
have identified a EMCS complex, comprising a family of uncharacterised mitochondrial outer …

The increase in human life expectancy has become a challenge to reduce the deleterious
consequences of aging. Nowadays, an increasing number of the population suffer from age …

Abstract Parkinson's disease (PD), known as one of the most universal neurodegenerative
diseases, is a serious threat to the health of the elderly. The current treatment has been …

In the last decades, the communication between the Endoplasmic reticulum (ER) and
mitochondria has obtained great attention: mitochondria-associated membranes (MAMs) …

Sirtuins are protein factors that can delay aging and alleviate age-related diseases through
multiple molecular pathways, mainly by promoting DNA damage repair, delaying telomere …