Currently, over five million Americans suffer with Alzheimer's disease (AD). In the absence of
a cure, this number could increase to 13.8 million by 2050. A critical goal of biomedical …

▪ Abstract The cAMP responsive element binding protein (CREB) is a nuclear protein that
modulates the transcription of genes with cAMP responsive elements in their promoters …

Using the techniques set out in the preceding paper (Muller et al., 1987), we investigated the
response of place cells to changes in the animal's environment. The standard apparatus …

We found that a short exercise period enhanced cognitive function on the Morris water maze
(MWM), such that exercised animals were significantly better than sedentary controls at …

THE human hippocampus has been implicated in memory1, in particular episodic2, 3 or
declarative4 memory. In rats, hippocampal lesions cause selective spatial deficits2, 5–7, and …

The cAMP-responsive element-binding protein (WEB) has been implicated in the activation
of protein synthesis required for long-term facilitation, a cellular model of memory in Aplysia …

This study investigated the respective roles of the hippocampus, the amygdala, and the
dorsal striatum in learning and memory. A standard set of experimental conditions for …

Although long-term potentiation (LTP) has been studied as the mechanism for hippocampus-
dependent learning and memory, evidence for this hypothesis is still incomplete. The mice …

The present experiments were designed to examine the hypothesis that the mammalian
brain contains anatomically distinct memory systems. Rats with bilateral lesions of caudate …

Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …