A properly functioning adaptive immune system signifies the best features of life. It is diverse
beyond compare, tolerant without fail, and capable of behaving appropriately with a myriad …

The characterization of human dendritic cell (DC) subsets is essential for the design of new
vaccines. We report the first detailed functional analysis of the human CD141+ DC subset …

HIV-1, hepatitis B virus, hepatitis C virus, and human papillomavirus type 16 cause
persistent infections that frequently precede cancer development. Virions of these viruses …

Clinical trials with direct administration of synthetic mRNAs encoding tumor antigens
demonstrated safety and induction of tumor-specific immune responses. Their proper …

Vascular endothelial growth factor (VEGF) inhibits differentiation and maturation of dendritic
cells (DC), suggesting a potential immunosuppressive role for this proangiogenic factor …

Tumors can induce generation and accumulation of the immunosuppressive cells such as
regulatory T cells in the tumor microenvironment, contributing to tumor escape from …

For effective cancer immunotherapy by vaccination, co-delivery of tumour antigens and
adjuvants to dendritic cells and subsequent activation of antigen-specific cytotoxic T cells …

Overlapping synthetic long peptides (SLPs) hold great promise for immunotherapy of
cancer. Poly (lactic-co-glycolic acid)(PLGA) nanoparticles (NPs) are being developed as …

Successful pulmonary clearance of the encapsulated yeast Cryptococcus neoformans
requires a T1 adaptive immune response. This response takes up to 3 weeks to fully …

Preclinical studies have suggested that purified populations of CD1c (BDCA-1+) blood-
derived dendritic cells (BDC) loaded with tumor-specific peptides may be a feasible option …