Interferons (IFNs) constitute the first line of defense against microbial infections particularly
against viruses. They provide antiviral properties to cells by inducing the expression of …

Inflammatory bowel disease (IBD) represents chronic recurrent intestinal inflammation
resulting from various factors. Crohn's disease (CD) and ulcerative colitis (UC) have been …

Checkpoint blockade with antibodies specific for the PD-1 and CTLA-4 inhibitory receptors
can induce durable responses in a wide range of human cancers. However, the …

In rare instances, pediatric SARS-CoV-2 infection results in a novel immunodysregulation
syndrome termed multisystem inflammatory syndrome in children (MIS-C). We compared …

Neutrophil extracellular traps (NETs) are extracellular structures, composed of nuclear DNA
and various proteins released from neutrophils. Evidence is growing that NETs exert …

Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that
most often occur after an overreactive immune system is activated by an acute systemic …

The complex pathogenesis of inflammatory bowel disease (IBD) explains the several
hurdles for finding an efficient approach to cure it. Nowadays, therapeutic protocols aim to …

T cells differentiate into highly diverse subsets and display plasticity depending on the
environment. Although lymphocytes are key mediators of inflammation, functional …

Oral drug delivery is a common route for management of inflammatory bowel disease (IBD)
but suffers from low bioavailability and systemic side effects during passage through the …

Autoimmune diseases have long been known to share a common pathogenesis involving a
dysregulated immune system with a failure to recognize self from non-self-antigens. This …