Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

The number of old people is rising worldwide, and advancing age is a major risk factor for
atherosclerotic cardiovascular disease. However, the mechanisms underlying this …

Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

The pathobiology of atherosclerotic disease requires further elucidation to discover new
approaches to address its high morbidity and mortality. To date, over 17 million …

Aging is associated with chronic systemic inflammation, which contributes to the
development of many age-related diseases, including vascular disease. The world's …

The historical view of vascular smooth muscle cells (VSMCs) in atherosclerosis is that
aberrant proliferation of VSMCs promotes plaque formation, but that VSMCs in advanced …

Cellular senescence is a state of irreversible cell cycle arrest associated with ageing.
Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular …

As we age, the innate immune system becomes dysregulated and is characterized by
persistent inflammatory responses that involve multiple immune and non-immune cell types …

Over the past millennia, life expectancy has drastically increased. While a mere 25 years
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …

Abstract Coronavirus Disease 2019 (COVID-19) is an ongoing public health emergency and
new knowledge about its immunopathogenic mechanisms is deemed necessary in the …