Cancers are a group of heterogeneous diseases characterized by the acquisition of
functional capabilities during the transition from a normal to a neoplastic state. Powerful …

Intratumor heterogeneity is a common characteristic across diverse cancer types and
presents challenges to current standards of treatment. Advancements in high-throughput …

Newborn microglia rapidly replenish the whole brain after selective elimination of most
microglia (> 99%) in adult mice. Previous studies reported that repopulated microglia were …

Bacteria colonize almost all parts of the human body and can differ significantly. However,
the population level transcriptomics measurements can only describe the average bacteria …

Deep sequencing has been revolutionizing biology and medicine in recent years, providing
single base‐level precision for our understanding of nucleic acid sequences in high …

Single-cell RNA-sequencing (scRNA-seq) has emerged as a revolutionary tool that allows
us to address scientific questions that eluded examination just a few years ago. With the …

Cells are the basic building blocks of organisms and each cell is unique. Single-cell RNA
sequencing has emerged as an indispensable tool to dissect the cellular heterogeneity and …

We present a survey of single-cell whole-genome amplification (WGA) methods, including
degenerate oligonucleotide–primed polymerase chain reaction (DOP-PCR), multiple …

The quantification of transcriptional variation in single cells, particularly within the same cell
population, is currently limited by the low sensitivity and high technical noise of single-cell …

Cell-to-cell variation and heterogeneity are fundamental and intrinsic characteristics of stem
cell populations, but these differences are masked when bulk cells are used for omic …