Obesity, the most common nutritional disorder in industrialized countries, is associated with
an increased mortality and morbidity of cardiovascular disease (CVD). Obesity is primarily …

Apelin and Elabela (ELA) are endogenous ligands of angiotensin domain type 1 receptor-
associated proteins (APJ). Apelin/ELA-APJ signal is widely distributed in the cardiovascular …

Apelin and its G protein-coupled receptor (GPCR) have emerged as a key signalling
pathway in the cardiovascular system. The peptide is a potent inotropic agent and …

Interest in the biology of white adipose tissue has increased dramatically since the discovery
of leptin in 1994. The identification of the product of the gene obese (ob) threw light on the …

The predicted protein encoded by the APJ gene discovered in 1993 was originally classified
as a class AG protein-coupled orphan receptor but was subsequently paired with a novel …

Apelin is the endogenous ligand for the previously orphaned G protein-coupled receptor,
APJ. This novel peptidic signalling pathway is widely represented in the heart and …

Apelin is a novel peptide that acts through the APJ receptor, sharing similarities with the
angiotensin II–angiotensin II type 1 receptor pathway. It is a peripheral vasodilator, powerful …

Apelin, the ligand for the angiotensin receptor like-1, has been implicated in the
pathogenesis of atrial fibrillation and heart failure. However, it is unknown if apelin has direct …

Patients with heart failure and decreased function frequently develop discoordinate
contraction because of electric activation delay. Often termed dyssynchrony, this further …

Apelin is an endogenous peptide ligand for the G protein-coupled receptor
APJ/AGTRL1/APLNR and is widely expressed throughout human body. In adult hearts …