[HTML][HTML] Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases
Monoclonal antibodies are being developed as therapeutics to complement drugs and
vaccines or to fill the gap where no drugs or vaccines exist. These therapeutic antibodies …
vaccines or to fill the gap where no drugs or vaccines exist. These therapeutic antibodies …
Current status of dengue therapeutics research and development
Dengue is a significant global health problem. Even though a vaccine against dengue is
now available, which is a notable achievement, its long-term protective efficacy against each …
now available, which is a notable achievement, its long-term protective efficacy against each …
Antibody-dependent enhancement of viral infections
R Kulkarni - Dynamics of immune activation in viral diseases, 2020 - Springer
Antiviral antibodies constitute an important component of the host immune response against
viral infections and serve to neutralize and reduce infectivity of the virus. However, these …
viral infections and serve to neutralize and reduce infectivity of the virus. However, these …
Dengue virus neutralizing antibody: a review of targets, cross-reactivity, and antibody-dependent enhancement
Dengue is the most common viral infection spread by mosquitoes, prevalent in tropical
countries. The acute dengue virus (DENV) infection is a benign and primarily febrile illness …
countries. The acute dengue virus (DENV) infection is a benign and primarily febrile illness …
Therapeutic efficacy of humanized monoclonal antibodies targeting dengue virus nonstructural protein 1 in the mouse model
SM Tien, PC Chang, YC Lai, YC Chuang… - PLoS …, 2022 - journals.plos.org
Dengue virus (DENV) which infects about 390 million people per year in tropical and
subtropical areas manifests various disease symptoms, ranging from fever to life-threatening …
subtropical areas manifests various disease symptoms, ranging from fever to life-threatening …
Dengue: an update on treatment options
CYY Chan, EE Ooi - Future microbiology, 2015 - Taylor & Francis
Dengue is the most important mosquito-borne viral pathogen globally, with approximately
100 million cases of acute dengue annually. Infection can result in severe, life-threatening …
100 million cases of acute dengue annually. Infection can result in severe, life-threatening …
Therapeutic effects of monoclonal antibody against dengue virus NS1 in a STAT1 knockout mouse model of dengue infection
SW Wan, PW Chen, CY Chen, YC Lai… - The Journal of …, 2017 - journals.aai.org
Dengue virus (DENV) is the causative agent of dengue fever, dengue hemorrhagic fever,
and dengue shock syndrome and is endemic to tropical and subtropical regions of the world …
and dengue shock syndrome and is endemic to tropical and subtropical regions of the world …
Utility, limitations, and future of non-human primates for dengue research and vaccine development
CA Sariol, LJ White - Frontiers in immunology, 2014 - frontiersin.org
Dengue is considered the most important emerging, human arboviruses, with worldwide
distribution in the tropics. Unfortunately, there are no licensed dengue vaccines available or …
distribution in the tropics. Unfortunately, there are no licensed dengue vaccines available or …
The mechanistic role of antibodies to dengue virus in protection and disease pathogenesis
Introduction: Dengue is a prevalent disease in tropical and subtropical countries with an
estimated 400 million people infected annually. While significant advancement has been …
estimated 400 million people infected annually. While significant advancement has been …
Machine-learning-assisted high-throughput identification of potent and stable neutralizing antibodies against all four dengue virus serotypes
P Natsrita, P Charoenkwan, W Shoombuatong… - Scientific Reports, 2024 - nature.com
Several computational methods have been developed to identify neutralizing antibodies
(NAbs) covering four dengue virus serotypes (DENV-1 to DENV-4); however, limitations of …
(NAbs) covering four dengue virus serotypes (DENV-1 to DENV-4); however, limitations of …