[HTML][HTML] Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

V Irani, AJ Guy, D Andrew, JG Beeson… - Molecular …, 2015 - Elsevier
Monoclonal antibodies are being developed as therapeutics to complement drugs and
vaccines or to fill the gap where no drugs or vaccines exist. These therapeutic antibodies …

Current status of dengue therapeutics research and development

JGH Low, EE Ooi, SG Vasudevan - The Journal of infectious …, 2017 - academic.oup.com
Dengue is a significant global health problem. Even though a vaccine against dengue is
now available, which is a notable achievement, its long-term protective efficacy against each …

Antibody-dependent enhancement of viral infections

R Kulkarni - Dynamics of immune activation in viral diseases, 2020 - Springer
Antiviral antibodies constitute an important component of the host immune response against
viral infections and serve to neutralize and reduce infectivity of the virus. However, these …

Dengue virus neutralizing antibody: a review of targets, cross-reactivity, and antibody-dependent enhancement

A Sarker, N Dhama, RD Gupta - Frontiers in immunology, 2023 - frontiersin.org
Dengue is the most common viral infection spread by mosquitoes, prevalent in tropical
countries. The acute dengue virus (DENV) infection is a benign and primarily febrile illness …

Therapeutic efficacy of humanized monoclonal antibodies targeting dengue virus nonstructural protein 1 in the mouse model

SM Tien, PC Chang, YC Lai, YC Chuang… - PLoS …, 2022 - journals.plos.org
Dengue virus (DENV) which infects about 390 million people per year in tropical and
subtropical areas manifests various disease symptoms, ranging from fever to life-threatening …

Dengue: an update on treatment options

CYY Chan, EE Ooi - Future microbiology, 2015 - Taylor & Francis
Dengue is the most important mosquito-borne viral pathogen globally, with approximately
100 million cases of acute dengue annually. Infection can result in severe, life-threatening …

Therapeutic effects of monoclonal antibody against dengue virus NS1 in a STAT1 knockout mouse model of dengue infection

SW Wan, PW Chen, CY Chen, YC Lai… - The Journal of …, 2017 - journals.aai.org
Dengue virus (DENV) is the causative agent of dengue fever, dengue hemorrhagic fever,
and dengue shock syndrome and is endemic to tropical and subtropical regions of the world …

Utility, limitations, and future of non-human primates for dengue research and vaccine development

CA Sariol, LJ White - Frontiers in immunology, 2014 - frontiersin.org
Dengue is considered the most important emerging, human arboviruses, with worldwide
distribution in the tropics. Unfortunately, there are no licensed dengue vaccines available or …

The mechanistic role of antibodies to dengue virus in protection and disease pathogenesis

ES Gan, DHR Ting, KR Chan - Expert Review of Anti-Infective …, 2017 - Taylor & Francis
Introduction: Dengue is a prevalent disease in tropical and subtropical countries with an
estimated 400 million people infected annually. While significant advancement has been …

Machine-learning-assisted high-throughput identification of potent and stable neutralizing antibodies against all four dengue virus serotypes

P Natsrita, P Charoenkwan, W Shoombuatong… - Scientific Reports, 2024 - nature.com
Several computational methods have been developed to identify neutralizing antibodies
(NAbs) covering four dengue virus serotypes (DENV-1 to DENV-4); however, limitations of …