The resurgence of tuberculosis worldwide has intensified research efforts directed at
examining the host defense and pathogenic mechanisms operative in Mycobacterium …

Mycobacterium tuberculosis is a highly successful pathogen that parasitizes the
macrophages of its host. Its success can be attributed directly to its ability to manipulate the …

Mycobacterium tuberculosis survives in antigen-presenting cells (APCs) such as
macrophages and dendritic cells. APCs present antigens in association with major …

Tuberculosis is a major cause of death around the world, with most of the 1.5 million deaths
per year attributable to the disease occurring in developing countries. This disease is …

MHC class II molecules are pivotal for the adaptive immune system, because they guide the
development and activation of CD4+ T helper cells. Fulfilling these functions requires that …

Phagocytosis provides innate immune cells with a mechanism to take up and destroy
pathogenic bacteria, apoptotic cells and other large particles. In some cases, however …

Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-
binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition …

In higher organisms a variety of host defense mechanisms control the resident microflora
and, in most cases, effectively prevent invasive microbial disease. However, it appears that …

Mycobacterium tuberculosis (MTB) induces vigorous immune responses, yet persists inside
macrophages, evading host immunity. MTB bacilli or lysate was found to inhibit macrophage …

Most people infected with Mycobacterium tuberculosis contain the initial infection and
develop latent tuberculosis. This state is characterised by evidence of an immune response …