Immune evasion and altered metabolism, where glucose utilization is diverted to increased
lactic acid production, are two fundamental hallmarks of cancer. Although lactic acid has …

Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …

Simple Summary The role of lactate in cancer described by Otto Warburg in 1927 states that
cancer cells uptake high amount of glucose with a marked increase in lactate production …

Transitions between epithelial and mesenchymal phenotypes–the epithelial to
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …

Prostate cancer (PCa) is one of the most prevalent malignancies in adult males. However,
PCa is resistant to multi-kinase inhibitors-based anti-angiogenic therapies, and the …

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

The complex cross‐talk of intricate intercellular signaling networks between the tumor and
stromal cells promotes cancer progression. Hypoxia is one of the most common conditions …

Metabolomic studies of body fluids show that immune‐mediated inflammatory diseases such
as rheumatoid arthritis (RA) are associated with metabolic disruption. This is likely to reflect …

This review of the basics of cancer metabolism focuses on exploiting the metabolic
differences between normal and cancer cells. The first part of the review covers the different …

Prostate cancer is the most common non-cutaneous cancer in men in the United States.
Cancer metabolism has emerged as a contemporary topic of great interest for improved …