Nanofluidic structures have over the last two decades emerged as a powerful platform for
detailed analysis of DNA on the kilobase pair length scale. When DNA is confined to a …

The human genome contains multiple layers of information that extend beyond the genetic
sequence. In fact, identical genetics do not necessarily yield identical phenotypes as evident …

Diseases and diagnoses are predominant in the human population. Early diagnosis of
etiological agents plays a vital role in the treatment of bacterial infections. Existing standard …

Background Identification of pathogens is crucial to efficiently treat and prevent bacterial
infections. However, existing diagnostic techniques are slow or have a too low resolution for …

Motivation Optical genome mapping (OGM) is a technique that extracts partial genomic
information from optically imaged and linearized DNA fragments containing fluorescently …

Motivation Efficient tapping into genomic information from a single microscopic image of an
intact DNA molecule is an outstanding challenge and its solution will open new frontiers in …

Optical DNA mapping (ODM) is based on fluorescent labeling, stretching and imaging of
single DNA molecules to obtain sequence-specific fluorescence profiles, DNA barcodes …

Methicillin-resistant Staphylococcus aureus (MRSA) is a multidrug-resistant bacterium with a
global presence in healthcare facilities as well as community settings. The resistance of …

Motivation Genomics-based diagnostic methods that are quick, precise, and economical are
essential for the advancement of precision medicine, with applications spanning the …

Stretching of DNA in nanoscale confinement allows for several important studies. The
genetic contents of the DNA can be visualized on the single DNA molecule level, and the …