The DNA repair endonuclease EndoMS/NucS is highly conserved in Archaea and
Actinobacteria. This enzyme is able to recognize and cleave dsDNA carrying a mismatched …

Forkhead-associated (FHA) domain proteins specifically recognize phosphorylated
threonine via the FHA domain and are involved in signal transduction in various processes …

Since hyperthermophilic Archaea (HA) thrive in high-temperature environments, which
accelerate the rates of deamination of base in DNA, their genomic stability is facing a severe …

The linear chromosome of Streptomyces exhibits a highly compartmentalized structure with
a conserved central region flanked by variable arms. As double strand break (DSB) repair …

The study of DNA repair in hyperthermophiles has the potential to elucidate the mechanisms
of genome integrity maintenance systems under extreme conditions. Previous biochemical …

The model haloarchaeon Haloferax volcanii is polyploid with about 20 copies of its major
chromosome. Recently it has been described that highly efficient intermolecular gene …

Single-stranded DNA-binding proteins (SSBs) have been regarded as indispensable
replication factors. Herein, we report that the genes encoding the canonical SSB (SisSSB) …

Since its invention, recombinant protein expression has greatly facilitated our understanding
of various cellular processes in different biological systems because theoretically this …

Les Streptomyces, bactéries ubiquistes des sols forestiers, présentent une grande plasticité
génomique. Ces bactéries possèdent un chromosome linéaire hautement compartimenté …

生物は遺伝情報を正しく維持するために, DNA に生じた様々な損傷を修復する機能を備えて突然
変異や細胞死などの有害な影響を回避している. 生物が有する種々の DNA 修復機能のうち …