Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint
blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of …

At the interface between the innate and adaptive immune system, dendritic cells (DCs) play
key roles in tumour immunity and hold a hitherto unrealized potential for cancer …

Local environmental factors influence CD8+ T cell priming in lymph nodes (LNs). Here, we
sought to understand how factors unique to the tumor-draining mediastinal LN (mLN) impact …

Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, shaping adaptive and innate immunity. Over the years, a …

Protection from harmful pathogens depends on activation of the immune system, which
relies on tight regulation of gene expression. Recently, the RNA modification N 6 …

Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve
T cell activation and effector differentiation. They are, likewise, involved in the induction and …

Antigen-presenting cells (APCs) are master regulators of the immune response by directly
interacting with T cells to orchestrate distinct functional outcomes. Several types of …

Indolent non-Hodgkin's lymphomas (iNHLs) are incurable with standard therapy and are
poorly responsive to checkpoint blockade. Although lymphoma cells are efficiently killed by …

Immunotherapy has emerged as an effective strategy for the prevention and treatment of a
variety of diseases, including cancer, infectious diseases, inflammatory diseases, and …

Cancer heterogeneity, a hallmark enabling clonal survival and therapy resistance, is shaped
by active immune responses. Antigen-specific T cells can control cancer, as revealed …