Significant innovations in next-generation sequencing techniques and bioinformatics tools
have impacted our appreciation and understanding of RNA. Practical RNA sequencing …

Understanding the systems-level actions of transcriptional responses to hormones provides
insight into how the genome is reprogrammed in response to environmental stimuli. Here …

Plants have adapted to tolerate and survive constantly changing environmental conditions
by reprogramming gene expression The dynamics of the contribution of alternative splicing …

Background Accurate and comprehensive annotation of transcript sequences is essential for
transcript quantification and differential gene and transcript expression analysis. Single …

Although accumulating evidence indicates that alternative splicing is aberrantly altered in
many cancers, the functional mechanism remains to be elucidated. Here, we show that …

ABSTRACT RNA-sequencing (RNA-seq) analysis of gene expression and alternative
splicing should be routine and robust but is often a bottleneck for biologists because of …

Plants re-program their gene expression when responding to changing environmental
conditions. Besides differential gene expression, extensive alternative splicing (AS) of pre …

Summary Wheat (Triticum aestivum L.), a globally important crop, is challenged by
increasing temperatures (heat stress, HS). However its polyploid nature, the incompleteness …

As the cost of sequencing drops rapidly, the amount of 'omics data increases exponentially,
making data visualization and interpretation—'tertiary 'analysis a bottleneck. Specialized …

Alternative splicing is an essential regulatory mechanism for gene expression in mammalian
cells contributing to protein, cellular, and species diversity. In cancer, alternative splicing is …