Connectomic reconstruction of a female Drosophila ventral nerve cord

A Azevedo, E Lesser, JS Phelps, B Mark, L Elabbady… - Nature, 2024 - nature.com
A deep understanding of how the brain controls behaviour requires mapping neural circuits
down to the muscles that they control. Here, we apply automated tools to segment neurons …

[HTML][HTML] Descending control of motor sequences in Drosophila

JH Simpson - Current Opinion in Neurobiology, 2024 - Elsevier
The descending neurons connecting the fly's brain to its ventral nerve cord respond to
sensory stimuli and evoke motor programs of varying complexity. Anatomical …

Transforming descending input into behavior: The organization of premotor circuits in the Drosophila Male Adult Nerve Cord connectome

HSJ Cheong, K Eichler, T Stürner, SK Asinof… - bioRxiv, 2023 - biorxiv.org
In most animals, a relatively small number of descending neurons (DNs) connect higher
brain centers in the animal's head to circuits and motor neurons (MNs) in the nerve cord of …

Neural Control of Naturalistic Behavior Choices

SK Asinof, GM Card - Annual Review of Neuroscience, 2024 - annualreviews.org
In the natural world, animals make decisions on an ongoing basis, continuously selecting
which action to undertake next. In the lab, however, the neural bases of decision processes …

Systematic annotation of a complete adult male Drosophila nerve cord connectome reveals principles of functional organisation

EC Marin, BJ Morris, T Stürner, AS Champion… - BioRxiv, 2023 - biorxiv.org
Our companion paper introduces the first completely proofread connectome of the nerve
cord of an animal that can walk or fly. The base connectome consists of neuronal …

Descending control and regulation of spontaneous flight turns in Drosophila

IG Ros, JJ Omoto, MH Dickinson - Current Biology, 2024 - cell.com
The clumped distribution of resources in the world has influenced the pattern of foraging
behavior since the origins of locomotion, selecting for a common search motif in which …

[HTML][HTML] Fine-grained descending control of steering in walking Drosophila

HH Yang, BE Brezovec, LS Capdevila, QX Vanderbeck… - Cell, 2024 - cell.com
Locomotion involves rhythmic limb movement patterns that originate in circuits outside the
brain. Purposeful locomotion requires descending commands from the brain, but we do not …

[HTML][HTML] Nested neural circuits generate distinct acoustic signals during Drosophila courtship

JL Lillvis, K Wang, HM Shiozaki, M Xu, DL Stern… - Current Biology, 2024 - cell.com
Many motor control systems generate multiple movements using a common set of muscles.
How are premotor circuits able to flexibly generate diverse movement patterns? Here, we …

Whole-body simulation of realistic fruit fly locomotion with deep reinforcement learning

R Vaxenburg, I Siwanowicz, J Merel, AA Robie… - bioRxiv, 2024 - biorxiv.org
The body of an animal influences how the nervous system produces behavior. Therefore,
detailed modeling of the neural control of sensorimotor behavior requires a detailed model …

[HTML][HTML] Presynaptic inhibition selectively suppresses leg proprioception in behaving Drosophila

CJ Dallmann, Y Luo, S Agrawal, GM Chou, A Cook… - …, 2024 - pmc.ncbi.nlm.nih.gov
Controlling arms and legs requires feedback from proprioceptive sensory neurons that
detect joint position and movement. Proprioceptive feedback must be tuned for different …