Transcription factors: Bridge between cell signaling and gene regulation
P Weidemüller, M Kholmatov, E Petsalaki… - …, 2021 - Wiley Online Library
Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as
differentiation and development, and of the cellular response to external perturbation …
differentiation and development, and of the cellular response to external perturbation …
Refactoring transcription factors for metabolic engineering
C Deng, Y Wu, X Lv, J Li, Y Liu, G Du, J Chen… - Biotechnology …, 2022 - Elsevier
Due to the ability to regulate target metabolic pathways globally and dynamically, metabolic
regulation systems composed of transcription factors have been widely used in metabolic …
regulation systems composed of transcription factors have been widely used in metabolic …
JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles
I Rauluseviciute, R Riudavets-Puig… - Nucleic Acids …, 2024 - academic.oup.com
Abstract JASPAR (https://jaspar. elixir. no/) is a widely-used open-access database
presenting manually curated high-quality and non-redundant DNA-binding profiles for …
presenting manually curated high-quality and non-redundant DNA-binding profiles for …
ChIP-Atlas 2021 update: a data-mining suite for exploring epigenomic landscapes by fully integrating ChIP-seq, ATAC-seq and Bisulfite-seq data
Abstract ChIP-Atlas (https://chip-atlas. org) is a web service providing both GUI-and API-
based data-mining tools to reveal the architecture of the transcription regulatory landscape …
based data-mining tools to reveal the architecture of the transcription regulatory landscape …
ReMap 2022: a database of Human, Mouse, Drosophila and Arabidopsis regulatory regions from an integrative analysis of DNA-binding sequencing experiments
F Hammal, P De Langen, A Bergon… - Nucleic acids …, 2022 - academic.oup.com
Abstract ReMap (https://remap. univ-amu. fr) aims to provide manually curated, high-quality
catalogs of regulatory regions resulting from a large-scale integrative analysis of DNA …
catalogs of regulatory regions resulting from a large-scale integrative analysis of DNA …
Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1
N Malik, BI Ferreira, PE Hollstein, SD Curtis, E Trefts… - Science, 2023 - science.org
Cells respond to mitochondrial poisons with rapid activation of the adenosine
monophosphate–activated protein kinase (AMPK), causing acute metabolic changes …
monophosphate–activated protein kinase (AMPK), causing acute metabolic changes …
Reductive carboxylation epigenetically instructs T cell differentiation
A Jaccard, T Wyss, N Maldonado-Pérez, JA Rath… - Nature, 2023 - nature.com
Protective immunity against pathogens or cancer is mediated by the activation and clonal
expansion of antigen-specific naive T cells into effector T cells. To sustain their rapid …
expansion of antigen-specific naive T cells into effector T cells. To sustain their rapid …
Distinct transcriptome architectures underlying lupus establishment and exacerbation
M Nakano, M Ota, Y Takeshima, Y Iwasaki, H Hatano… - Cell, 2022 - cell.com
Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple
immune cells. To elucidate SLE pathogenesis, it is essential to understand the dysregulated …
immune cells. To elucidate SLE pathogenesis, it is essential to understand the dysregulated …
HOCOMOCO in 2024: a rebuild of the curated collection of binding models for human and mouse transcription factors
We present a major update of the HOCOMOCO collection that provides DNA binding
specificity patterns of 949 human transcription factors and 720 mouse orthologs. To make …
specificity patterns of 949 human transcription factors and 720 mouse orthologs. To make …
Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes
Epigenetic dysregulation may influence disease progression. Here we explore whether
epigenetic alterations in human pancreatic islets impact insulin secretion and type 2 …
epigenetic alterations in human pancreatic islets impact insulin secretion and type 2 …