Recent advances in microfluidic technologies for cell-to-cell interaction studies

M Rothbauer, H Zirath, P Ertl - Lab on a Chip, 2018 - pubs.rsc.org
Microfluidic cell cultures are ideally positioned to become the next generation of in vitro
diagnostic tools for biomedical research, where key biological processes such as cell …

Stem cells differentiation into insulin-producing cells (IPCs): recent advances and current challenges

IBB Silva, CH Kimura, VP Colantoni… - Stem cell research & …, 2022 - Springer
Type 1 diabetes mellitus (T1D) is a chronic disease characterized by an autoimmune
destruction of insulin-producing β-pancreatic cells. Although many advances have been …

Osteoimmunomodulatory nanoparticles for bone regeneration

J Wen, D Cai, W Gao, R He, Y Li, Y Zhou, T Klein… - Nanomaterials, 2023 - mdpi.com
Treatment of large bone fractures remains a challenge for orthopedists. Bone regeneration
is a complex process that includes skeletal cells such as osteoblasts, osteoclasts, and …

Biomaterials in co-culture systems: towards optimizing tissue integration and cell signaling within scaffolds

KG Battiston, JWC Cheung, D Jain, JP Santerre - Biomaterials, 2014 - Elsevier
Most natural tissues consist of multi-cellular systems made up of two or more cell types.
However, some of these tissues may not regenerate themselves following tissue injury or …

[HTML][HTML] Organ-specific endothelial cell heterogenicity and its impact on regenerative medicine and biomedical engineering applications

M Urbanczyk, A Zbinden, K Schenke-Layland - Advanced Drug Delivery …, 2022 - Elsevier
Endothelial cells (ECs) are a key cellular component of the vascular system as they form the
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …

Formation of well-defined embryoid bodies from dissociated human induced pluripotent stem cells using microfabricated cell-repellent microwell arrays

G Pettinato, X Wen, N Zhang - Scientific reports, 2014 - nature.com
A simple, scalable and reproducible technology that allows direct formation of large
numbers of homogeneous and synchronized embryoid bodies (EBs) of defined sizes from …

Stem cell microencapsulation for phenotypic control, bioprocessing, and transplantation

JL Wilson, TC McDevitt - Biotechnology and bioengineering, 2013 - Wiley Online Library
Cell microencapsulation has been utilized for decades as a means to shield cells from the
external environment while simultaneously permitting transport of oxygen, nutrients, and …

Microfluidic fabrication of microcarriers with sequential delivery of VEGF and BMP-2 for bone regeneration

E Dashtimoghadam, F Fahimipour, N Tongas… - Scientific Reports, 2020 - nature.com
Wound instability and poor functional vascularization in bone tissue engineering lead to lack
of tissue integration and ultimate failure of engineered grafts. In order to harness the …

[HTML][HTML] Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro …

MC Cornejo, SK Cho, C Giannarelli, JC Iatridis… - Osteoarthritis and …, 2015 - Elsevier
Background Chronic low back pain can be associated with the pathological ingrowth of
blood vessels and nerves into intervertebral discs (IVDs). The notochord patterns the IVD …

Conventional and novel stem cell based therapies for androgenic alopecia

D Talavera-Adame, D Newman… - Stem Cells and Cloning …, 2017 - Taylor & Francis
The prevalence of androgenic alopecia (AGA) increases with age and it affects both men
and women. Patients diagnosed with AGA may experience decreased quality of life …