Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism
A Wahlström, SI Sayin, HU Marschall, F Bäckhed - Cell metabolism, 2016 - cell.com
The gut microbiota is considered a metabolic" organ" that not only facilitates harvesting of
nutrients and energy from the ingested food but also produces numerous metabolites that …
nutrients and energy from the ingested food but also produces numerous metabolites that …
[HTML][HTML] The influence of the gut microbiota on the bioavailability of oral drugs
X Zhang, Y Han, W Huang, M Jin, Z Gao - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Due to its safety, convenience, low cost and good compliance, oral administration attracts
lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory …
lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory …
Systematic assessment of secondary bile acid metabolism in gut microbes reveals distinct metabolic capabilities in inflammatory bowel disease
Background The human gut microbiome performs important functions in human health and
disease. A classic example for host-gut microbial co-metabolism is host biosynthesis of …
disease. A classic example for host-gut microbial co-metabolism is host biosynthesis of …
Metabolism of cholesterol and bile acids by the gut microbiota
P Gérard - Pathogens, 2013 - mdpi.com
The human gastro-intestinal tract hosts a complex and diverse microbial community, whose
collective genetic coding capacity vastly exceeds that of the human genome. As a …
collective genetic coding capacity vastly exceeds that of the human genome. As a …
Bile salt biotransformations by human intestinal bacteria
JM Ridlon, DJ Kang, PB Hylemon - Journal of lipid research, 2006 - ASBMB
Secondary bile acids, produced solely by intestinal bacteria, can accumulate to high levels
in the enterohepatic circulation of some individuals and may contribute to the pathogenesis …
in the enterohepatic circulation of some individuals and may contribute to the pathogenesis …
Bile acid metabolism and signaling in cholestasis, inflammation, and cancer
Bile acids are synthesized from cholesterol in the liver. Some cytochrome P450 (CYP)
enzymes play key roles in bile acid synthesis. Bile acids are physiological detergent …
enzymes play key roles in bile acid synthesis. Bile acids are physiological detergent …
[HTML][HTML] The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics
The human body is now viewed as a complex ecosystem that on a cellular and gene level is
mainly prokaryotic. The mammalian liver synthesizes and secretes hydrophilic primary bile …
mainly prokaryotic. The mammalian liver synthesizes and secretes hydrophilic primary bile …
Another renaissance for bile acid gastrointestinal microbiology
JM Ridlon, HR Gaskins - Nature Reviews Gastroenterology & …, 2024 - nature.com
The field of bile acid microbiology in the gastrointestinal tract is going through a current
rebirth after a peak of activity in the late 1970s and early 1980s. This renewed activity is a …
rebirth after a peak of activity in the late 1970s and early 1980s. This renewed activity is a …
Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes
The gut microbiome of vertebrates is capable of numerous biotransformations of bile acids,
which are responsible for intestinal lipid digestion and function as key nutrient-signaling …
which are responsible for intestinal lipid digestion and function as key nutrient-signaling …
The 'in vivo lifestyle' of bile acid 7α-dehydroxylating bacteria: comparative genomics, metatranscriptomic, and bile acid metabolomics analysis of a defined microbial …
The formation of secondary bile acids by gut microbes is a current topic of considerable
biomedical interest. However, a detailed understanding of the biology of anaerobic bacteria …
biomedical interest. However, a detailed understanding of the biology of anaerobic bacteria …