Mitochondrial dynamics in adaptive and maladaptive cellular stress responses
Mitochondria sense and respond to many stressors and can support cell survival or death
through energy production and signalling pathways. Mitochondrial responses depend on …
through energy production and signalling pathways. Mitochondrial responses depend on …
[HTML][HTML] Coming together to define membrane contact sites
Close proximities between organelles have been described for decades. However, only
recently a specific field dealing with organelle communication at membrane contact sites …
recently a specific field dealing with organelle communication at membrane contact sites …
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance
P Romani, N Nirchio, M Arboit, V Barbieri, A Tosi… - Nature cell …, 2022 - nature.com
Metastatic breast cancer cells disseminate to organs with a soft microenvironment. Whether
and how the mechanical properties of the local tissue influence their response to treatment …
and how the mechanical properties of the local tissue influence their response to treatment …
[HTML][HTML] Calcium, mitochondria and cell metabolism: A functional triangle in bioenergetics
The versatility of mitochondrial metabolism and its fine adjustments to specific physiological
or pathological conditions regulate fundamental cell pathways, ranging from proliferation to …
or pathological conditions regulate fundamental cell pathways, ranging from proliferation to …
New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury
As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …
CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes
Z Zhang, H Zhou, W Gu, Y Wei, S Mou, Y Wang… - Nature Chemical …, 2024 - nature.com
Ferroptosis is iron-dependent oxidative cell death. Labile iron and polyunsaturated fatty acid
(PUFA)-containing lipids are two critical factors for ferroptosis execution. Many processes …
(PUFA)-containing lipids are two critical factors for ferroptosis execution. Many processes …
Current methods to analyze lysosome morphology, positioning, motility and function
Since the discovery of lysosomes more than 70 years ago, much has been learned about
the functions of these organelles. Lysosomes were regarded as exclusively degradative …
the functions of these organelles. Lysosomes were regarded as exclusively degradative …
[HTML][HTML] Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact
The understanding that organelles are not floating in the cytosol, but rather held in an
organized yet dynamic interplay through membrane contact sites, is altering the way we …
organized yet dynamic interplay through membrane contact sites, is altering the way we …
Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics
Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune
bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the …
bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the …
Endoplasmic reticulum–mitochondria signaling in neurons and neurodegenerative diseases
A Markovinovic, J Greig… - Journal of Cell …, 2022 - journals.biologists.com
Recent advances have revealed common pathological changes in neurodegenerative
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …
diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral …