Modulating biomolecular condensates: a novel approach to drug discovery
In the past decade, membraneless assemblies known as biomolecular condensates have
been reported to play key roles in many cellular functions by compartmentalizing specific …
been reported to play key roles in many cellular functions by compartmentalizing specific …
Selective autophagy receptor p62/SQSTM1, a pivotal player in stress and aging
AV Kumar, J Mills, LR Lapierre - Frontiers in cell and developmental …, 2022 - frontiersin.org
Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads
to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by …
to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by …
Regulation of nucleo-cytosolic 26S proteasome translocation by aromatic amino acids via mTOR is essential for cell survival under stress
The proteasome is responsible for removal of ubiquitinated proteins. Although several
aspects of its regulation (eg, assembly, composition, and post-translational modifications) …
aspects of its regulation (eg, assembly, composition, and post-translational modifications) …
PhaSepDB in 2022: annotating phase separation-related proteins with droplet states, co-phase separation partners and other experimental information
Phase separation (PS) proteins form droplets to regulate myriad membraneless organelles
(MLOs) and cellular pathways such as transcription, signaling transduction and protein …
(MLOs) and cellular pathways such as transcription, signaling transduction and protein …
Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation
The phenomenon of protein phase separation (PPS) underlies a wide range of cellular
functions. Correspondingly, the dysregulation of the PPS process has been associated with …
functions. Correspondingly, the dysregulation of the PPS process has been associated with …
Proteasome substrate receptors and their therapeutic potential
V Osei-Amponsa, KJ Walters - Trends in biochemical sciences, 2022 - cell.com
The ubiquitin-proteasome system (UPS) is critical for protein quality control and regulating
protein lifespans. Following ubiquitination, UPS substrates bind multidomain receptors that …
protein lifespans. Following ubiquitination, UPS substrates bind multidomain receptors that …
Orphan quality control shapes network dynamics and gene expression
All eukaryotes require intricate protein networks to translate developmental signals into
accurate cell fate decisions. Mutations that disturb interactions between network …
accurate cell fate decisions. Mutations that disturb interactions between network …
Intracellular localization of the proteasome in response to stress conditions
C Enenkel, RW Kang, F Wilfling, OP Ernst - Journal of Biological Chemistry, 2022 - ASBMB
The ubiquitin–proteasome system fulfills an essential role in regulating protein homeostasis
by spatially and temporally controlling proteolysis in an ATP-and ubiquitin-dependent …
by spatially and temporally controlling proteolysis in an ATP-and ubiquitin-dependent …
Loss of PML nuclear bodies in familial amyotrophic lateral sclerosis-frontotemporal dementia
F Antoniani, M Cimino, L Mediani, J Vinet… - Cell death …, 2023 - nature.com
Abstract Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two
neurodegenerative disorders that share genetic causes and pathogenic mechanisms. The …
neurodegenerative disorders that share genetic causes and pathogenic mechanisms. The …
Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains
Ubiquitin‐binding shuttle UBQLN2 mediates crosstalk between proteasomal degradation
and autophagy, likely via interactions with K48‐and K63‐linked polyubiquitin chains …
and autophagy, likely via interactions with K48‐and K63‐linked polyubiquitin chains …