Adipose tissue depots can exist in close association with other organs, where they assume
diverse, often non-traditional functions. In stem cell-rich skin, bone marrow, and mammary …

Between the years 2010 and 2012, the lifetime probability of developing female breast
cancer was 12.3%, or approximately 1 in 8. Worldwide, breast cancer is the most common …

The extracellular matrix (ECM) is increasingly recognized as an important regulator in breast
cancer. ECM in breast cancer development features numerous changes in composition and …

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that
disproportionately affects BRCA1 mutation carriers and young women of African origin …

Cancer invasion is a cell-and tissue-driven process for which the physical, cellular, and
molecular determinants adapt and react throughout the progression of the disease. Cancer …

Breast cancer arising at a young age is relatively uncommon, particularly in the developed
world. Several studies have demonstrated that younger patients often experience a more …

Breast cancer is an increasing public health problem. Substantial advances have been
made in the treatment of breast cancer, but the introduction of methods to predict women at …

Neoplastic cells recruit fibroblasts through various growth factors and cytokines. These
“cancer-associated fibroblasts”(CAF) actively interact with neoplastic cells and form a …

The tumor stroma is no longer seen solely as physical support for mutated epithelial cells but
as an important modulator and even a driver of tumorigenicity. Within the tumor stromal …

Ductal carcinoma in situ (DCIS) is an intraductal neoplastic proliferation of epithelial cells
that is separated from the breast stroma by an intact layer of basement membrane and …