Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …

Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

Biological membranes formed of amphipathic lipid bilayers provide chemical barriers to
separate cells from their external environments and define subcellular compartments …

Nanodiscs are soluble nanoscale phospholipid bilayers which can self-assemble integral
membrane proteins for biophysical, enzymatic or structural investigations. This means for …

Self-assembled phospholipid bilayer Nanodiscs have become an important and versatile
tool among model membrane systems to functionally reconstitute membrane proteins …

Using a recently described self-assembly process (Bayburt, TH; Grinkova, YV; Sligar, SG
Nano Letters 2002, 2, 853− 856), we prepared soluble monodisperse discoidal lipid/protein …

Giant unilamellar vesicles or GUVs are systems of choice as biomimetic models of cellular
membranes. Although a variety of procedures exist for making single walled vesicles of tens …

One-third of eukaryotic proteins are integrated within membranes, as are the targets of 40%
of approved drugs. However, the lack of a general means of solubilizing, stabilizing and …

Biological membranes and membrane proteins, responsible for numerous exciting
biological processes, present one of the paramount challenges in biophysics today …

The native environment of membrane proteins is complex and scientists have felt the need
to simplify it to reduce the number of varying parameters. However, experimental problems …