The current state of peptide drug discovery: back to the future?
A Henninot, JC Collins, JM Nuss - Journal of medicinal chemistry, 2018 - ACS Publications
Over the past decade, peptide drug discovery has experienced a revival of interest and
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …
scientific momentum, as the pharmaceutical industry has come to appreciate the role that …
Nanodiscs in membrane biochemistry and biophysics
IG Denisov, SG Sligar - Chemical reviews, 2017 - ACS Publications
Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …
transport, development, and many other biochemical and biophysical processes which …
Native mass spectrometry of membrane proteins
Biological membranes formed of amphipathic lipid bilayers provide chemical barriers to
separate cells from their external environments and define subcellular compartments …
separate cells from their external environments and define subcellular compartments …
[HTML][HTML] Membrane protein assembly into Nanodiscs
TH Bayburt, SG Sligar - FEBS letters, 2010 - Elsevier
Nanodiscs are soluble nanoscale phospholipid bilayers which can self-assemble integral
membrane proteins for biophysical, enzymatic or structural investigations. This means for …
membrane proteins for biophysical, enzymatic or structural investigations. This means for …
Reconstitution of membrane proteins in phospholipid bilayer nanodiscs
TK Ritchie, YV Grinkova, TH Bayburt, IG Denisov… - Methods in …, 2009 - Elsevier
Self-assembled phospholipid bilayer Nanodiscs have become an important and versatile
tool among model membrane systems to functionally reconstitute membrane proteins …
tool among model membrane systems to functionally reconstitute membrane proteins …
Directed self-assembly of monodisperse phospholipid bilayer Nanodiscs with controlled size
IG Denisov, YV Grinkova, AA Lazarides… - Journal of the …, 2004 - ACS Publications
Using a recently described self-assembly process (Bayburt, TH; Grinkova, YV; Sligar, SG
Nano Letters 2002, 2, 853− 856), we prepared soluble monodisperse discoidal lipid/protein …
Nano Letters 2002, 2, 853− 856), we prepared soluble monodisperse discoidal lipid/protein …
[HTML][HTML] Gel-assisted formation of giant unilamellar vesicles
A Weinberger, FC Tsai, GH Koenderink, TF Schmidt… - Biophysical journal, 2013 - cell.com
Giant unilamellar vesicles or GUVs are systems of choice as biomimetic models of cellular
membranes. Although a variety of procedures exist for making single walled vesicles of tens …
membranes. Although a variety of procedures exist for making single walled vesicles of tens …
Membrane proteins solubilized intact in lipid containing nanoparticles bounded by styrene maleic acid copolymer
TJ Knowles, R Finka, C Smith, YP Lin… - Journal of the …, 2009 - ACS Publications
One-third of eukaryotic proteins are integrated within membranes, as are the targets of 40%
of approved drugs. However, the lack of a general means of solubilizing, stabilizing and …
of approved drugs. However, the lack of a general means of solubilizing, stabilizing and …
[HTML][HTML] The magic of bicelles lights up membrane protein structure
UHN Dürr, M Gildenberg, A Ramamoorthy - Chemical reviews, 2012 - ACS Publications
Biological membranes and membrane proteins, responsible for numerous exciting
biological processes, present one of the paramount challenges in biophysics today …
biological processes, present one of the paramount challenges in biophysics today …
[HTML][HTML] Choosing membrane mimetics for NMR structural studies of transmembrane proteins
DE Warschawski, AA Arnold, M Beaugrand… - … et Biophysica Acta (BBA …, 2011 - Elsevier
The native environment of membrane proteins is complex and scientists have felt the need
to simplify it to reduce the number of varying parameters. However, experimental problems …
to simplify it to reduce the number of varying parameters. However, experimental problems …