The basement membrane is a thin but dense, sheet-like specialized type of extracellular
matrix that has remarkably diverse functions tailored to individual tissues and organs. Tightly …

The formation of human enamel is highly regulated at the molecular level and involves
thousands of genes. Requisites for development of this highly mineralized tissue include cell …

Despite some evidence of genetic and environmental factors on molar-incisor
hypomineralization (MIH), its aetiology remains unclear. This family-based genetic …

Ameloblasts are specialized cells derived from the dental epithelium that produce enamel, a
hierarchically structured tissue comprised of highly elongated hydroxylapatite (OHAp) …

Biomineralization, the generation of hard tissues of living organisms, is a process strictly
regulated by hormones, enzymes and a range of regulatory proteins of which several …

Tissue engineering (TE) is a multidisciplinary research field aiming at the regeneration,
restoration, or replacement of damaged tissues and organs. Classical TE approaches …

During development, Dlx3 is expressed in ectodermal appendages such as hair and teeth.
Thus far, the evidence that Dlx3 plays a crucial role in tooth development comes from reports …

Objectives Dental caries is a widespread multifactorial disease, caused by the
demineralization of hard dental tissues. Susceptibility to dental caries is partially genetically …

Tooth formation relies on two types of dental cell populations, namely, the dental epithelium
and dental mesenchyme, and the interactions between these cell populations are important …

Background Polarity is necessary for epithelial cells to perform distinct functions at their
apical and basal surfaces. Oral epithelial cell-derived ameloblasts at secretory stage (SABs) …