Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Lipid metabolism, in particular the synthesis of fatty acids (FAs), is an essential cellular
process that converts nutrients into metabolic intermediates for membrane biosynthesis …

Lipid metabolic reprogramming is involved in mediating tamoxifen (TAM) response in breast
cancer cells. Published microarray data indicated that ATP citrate lyase (ACLY) is …

Cancer cells are often exposed to a metabolically challenging environment with scarce
availability of oxygen and nutrients. This metabolic stress leads to changes in the balance …

Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated
fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a …

A functional genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2)
contributes to cancer cell growth under low-oxygen and lipid-depleted conditions …

Acetyl-CoA represents a central node of carbon metabolism that plays a key role in
bioenergetics, cell proliferation, and the regulation of gene expression. Highly glycolytic or …

Besides the conventional carbon sources, acetyl-CoA has recently been shown to be
generated from acetate in various types of cancers, where it promotes lipid synthesis and …

Lipids form a diverse group of water‐insoluble molecules that include triacylglycerides,
phosphoglycerides, sterols and sphingolipids. They play several important roles at cellular …