Role of cholinergic signaling in Alzheimer's disease

ZR Chen, JB Huang, SL Yang, FF Hong - Molecules, 2022 - mdpi.com
Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal
transduction related to memory and learning ability. Alzheimer's disease (AD), a progressive …

The cholinergic system in the pathophysiology and treatment of Alzheimer's disease

H Hampel, MM Mesulam, AC Cuello, MR Farlow… - Brain, 2018 - academic.oup.com
Cholinergic synapses are ubiquitous in the human central nervous system. Their high
density in the thalamus, striatum, limbic system, and neocortex suggest that cholinergic …

Neurobiochemical cross-talk between COVID-19 and Alzheimer's disease

MA Rahman, K Islam, S Rahman, M Alamin - Molecular neurobiology, 2021 - Springer
COVID-19, the global threat to humanity, shares etiological cofactors with multiple diseases
including Alzheimer's disease (AD). Understanding the common links between COVID-19 …

Resveratrol-selenium nanoparticles alleviate neuroinflammation and neurotoxicity in a rat model of Alzheimer's disease by regulating Sirt1/miRNA-134/GSK3β …

OAR Abozaid, MW Sallam, S El-Sonbaty… - … Trace Element Research, 2022 - Springer
Alzheimer's disease (AD) is a brain disorder associated with a gradual weakening in
neurocognitive functions, neuroinflammation, and impaired signaling pathways. Resveratrol …

Exercise-induced brain-derived neurotrophic factor expression: Therapeutic implications for Alzheimer's dementia

R Wang, RMD Holsinger - Ageing research reviews, 2018 - Elsevier
Emerging evidence indicates that moderate intensity aerobic exercise is positively
correlated with cognitive function and memory. However, the exact mechanisms underlying …

[HTML][HTML] Alzheimer's disease puzzle: delving into pathogenesis hypotheses

M Nasb, W Tao, N Chen - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by both
amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of …

Chemical genetic activation of the cholinergic basal forebrain hippocampal circuit rescues memory loss in Alzheimer's disease

W Liu, J Li, M Yang, X Ke, Y Dai, H Lin, S Wang… - Alzheimer's research & …, 2022 - Springer
Background The degeneration of the cholinergic circuit from the basal forebrain to the
hippocampus contributes to memory loss in patients suffering from Alzheimer's disease …

Cholinergic basal forebrain degeneration due to sleep-disordered breathing exacerbates pathology in a mouse model of Alzheimer's disease

L Qian, O Rawashdeh, L Kasas, MR Milne… - Nature …, 2022 - nature.com
Although epidemiological studies indicate that sleep-disordered breathing (SDB) such as
obstructive sleep apnea is a strong risk factor for the development of Alzheimer's disease …

Reconsideration of anticholinesterase therapeutic strategies against Alzheimer's disease

H Wang, H Zhang - ACS chemical neuroscience, 2018 - ACS Publications
Alzheimer's disease (AD) is well-known as a severe neurodegeneration disease involving
complicated etiologies, and cholinesterase inhibition remain the prevailing mode of clinical …

Improving anti-neurodegenerative benefits of acetylcholinesterase inhibitors in Alzheimer's disease: are irreversible inhibitors the future?

DE Moss - International journal of molecular sciences, 2020 - mdpi.com
Decades of research have produced no effective method to prevent, delay the onset, or slow
the progression of Alzheimer's disease (AD). In contrast to these failures …