Brain accumulation of the amyloid-β (Aβ) peptide is believed to be the initial event in the
Alzheimer disease (AD) process. Aβ accumulation begins 15–20 years before clinical …

Alzheimer's disease (AD) is a neurodegenerative disease associated with senile plaques
(SP) and neurofibrillary tangles (NFTs) in the brain. With aging of the population, AD has …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with a complex
pathogenesis. Senile plaques composed of the amyloid-β (Aβ) peptide in the brain are the …

Amyloid‐β (Aβ) dysmetabolism is tightly associated with pathological processes in
Alzheimer's disease (AD). Currently, it is thought that, in addition to Aβ fibrils that give rise to …

Introduction: The amyloid hypothesis of Alzheimer's disease (AD) affirms that brain
accumulation of amyloid-β (Aβ) oligomers and soluble aggregates represent the major …

Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized
pathologically by extracellular deposition of β-amyloid (Aβ) into senile plaques and …

Dysregulation of calcium homeostasis has been linked to multiple neurological diseases. In
addition to excitotoxic neuronal cell death observed following stroke, a growing number of …

Alzheimer's disease (AD) is a pervasive neurodegenerative disorder, and new approaches
for its prevention and therapy are critically needed. Here, we elucidate a gut-microbiome …

Several cell-surface receptors for neurotoxic forms of amyloid-β (Aβ) have been described,
but their molecular interactions with Aβ assemblies and their relative contributions to …

Alzheimer's disease is believed to begin with synaptic dysfunction caused by soluble Aβ
oligomers. When this oligomer hypothesis was proposed in 2002, there was no direct …