Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important
roles in synaptic development and plasticity. While its importance in fundamental physiology …

Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing
pattern and is one of the most frequently performed behavioural activities in rodents. In this …

Obsessive–compulsive disorder (OCD) is characterized by repetitive thoughts and
behaviours that are experienced as unwanted. Family and twin studies have demonstrated …

Corticostriatal projections are essential components of forebrain circuits and are widely
involved in motivated behaviour. These axonal projections are formed by two distinct …

Autism spectrum disorders (ASDs) comprise a range of disorders that share a core of
neurobehavioural deficits characterized by widespread abnormalities in social interactions …

Although cortico-striato-thalamo-cortical (CSTC) circuit dysregulation is correlated with
obsessive compulsive disorder (OCD), causation cannot be tested in humans. We used …

Here, we review the neural circuit bases of habits, compulsions, and addictions, behaviors
which are all characterized by relatively automatic action performance. We discuss relevant …

Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive
thoughts and urges and repetitive, intentional behaviors that cause significant distress and …

The plus-maze, the light–dark box and the open-field are the main current tests of
unconditioned anxiety for mice and rats. Despite their disappointing achievements, they …

Obsessive compulsive disorder is prevalent, disabling, incompletely understood, and often
resistant to current therapies. Established treatments consist of specialized cognitive …