Introduction Spinal cord injury (SCI) affects 25,000–50,000 people around the world each
year and there is no cure for SCI patients currently. The primary injury damages spinal cord …

Traumatic spinal cord injury is a life-changing condition with a significant socio-economic
impact on patients, their relatives, their caregivers, and even the community. Despite …

When the protein or calcium homeostasis of the endoplasmic reticulum (ER) is adversely
altered, cells experience ER stress that leads to various diseases including …

Neuromyelitis optica is a chronic neuroinflammatory disease, which primarily targets
astrocytes and often results in severe axon injury of unknown mechanism. Neuromyelitis …

Spinal cord injury (SCI), resulting in damage of the normal structure and function of the
spinal cord, would do great harm to patients, physically and psychologically. The …

Endothelial damage, astrogliosis, microgliosis, and neuronal degeneration are the most
common events after spinal cord injury (SCI). Studies highlighted that studying the …

Occupational and environmental exposure to acrylamide (ACR) can cause selective
peripheral and central nerve fiber degeneration. IP3R-3 is an important transmembrane Ca …

Spinal cord injury (SCI) can result in the permanent loss of mobility, sensation, and
autonomic function. Secondary degeneration after SCI both initiates and propagates a …

Abstract Tuberous Sclerosis Complex (TSC) is a multisystem genetic disorder characterized
by the development of benign tumors in various organs, including the brain, and is often …

Ryanodine receptors (RyRs) mediate calcium release from calcium stores and have been
implicated in axonal degeneration. Here, we use an intravital imaging approach to …