[HTML][HTML] The controlled cortical impact model: applications, considerations for researchers, and future directions
ND Osier, CE Dixon - Frontiers in neurology, 2016 - frontiersin.org
Controlled cortical impact (CCI) is a mechanical model of traumatic brain injury (TBI) that
was developed nearly 30 years ago with the goal of creating a testing platform to determine …
was developed nearly 30 years ago with the goal of creating a testing platform to determine …
The holy grail of epilepsy prevention: Preclinical approaches to antiepileptogenic treatments
W Löscher - Neuropharmacology, 2020 - Elsevier
A variety of acute brain insults can induce epileptogenesis, a complex process that results in
acquired epilepsy. Despite advances in understanding mechanisms of epileptogenesis …
acquired epilepsy. Despite advances in understanding mechanisms of epileptogenesis …
Electroencephalographic periodic discharges and frequency-dependent brain tissue hypoxia in acute brain injury
Importance Periodic discharges (PDs) that do not meet seizure criteria, also termed theictal
interictal continuum, are pervasive on electroencephalographic (EEG) recordings after acute …
interictal continuum, are pervasive on electroencephalographic (EEG) recordings after acute …
[HTML][HTML] High arterial oxygen levels and supplemental oxygen administration in traumatic brain injury: insights from CENTER-TBI and OzENTER-TBI
Purpose The effect of high arterial oxygen levels and supplemental oxygen administration
on outcomes in traumatic brain injury (TBI) is debated, and data from large cohorts of TBI …
on outcomes in traumatic brain injury (TBI) is debated, and data from large cohorts of TBI …
Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?
Prevention of epilepsy is a great unmet need. Acute central nervous system (CNS) insults
such as traumatic brain injury (TBI), cerebrovascular accidents (CVA), and CNS infections …
such as traumatic brain injury (TBI), cerebrovascular accidents (CVA), and CNS infections …
Blood-based traumatic brain injury biomarkers–Clinical utilities and regulatory pathways in the United States, Europe and Canada
Introduction Traumatic brain injury (TBI) is a major global health issue, resulting in
debilitating consequences to families, communities, and health-care systems. Prior research …
debilitating consequences to families, communities, and health-care systems. Prior research …
Pre-clinical testing of therapies for traumatic brain injury
DS DeWitt, BE Hawkins, CE Dixon… - Journal of …, 2018 - liebertpub.com
Despite the large number of promising neuroprotective agents identified in experimental
traumatic brain injury (TBI) studies, none has yet shown meaningful improvements in long …
traumatic brain injury (TBI) studies, none has yet shown meaningful improvements in long …
Traumatic brain injury and traumatic spinal cord injury
Traumatic Brain Injury and Traumatic Spinal Cord Injury : CONTINUUM: Lifelong Learning in
Neurology Account Register Activate Subscription Help Subscribe American Academy of …
Neurology Account Register Activate Subscription Help Subscribe American Academy of …
[HTML][HTML] Circulating GFAP and Iba-1 levels are associated with pathophysiological sequelae in the thalamus in a pig model of mild TBI
Serum biomarkers are promising tools for evaluating patients following traumatic brain injury
(TBI). However, their relationship with diffuse histopathology remains unclear. Additionally …
(TBI). However, their relationship with diffuse histopathology remains unclear. Additionally …
Insight into pre-clinical models of traumatic brain injury using circulating brain damage biomarkers: operation brain trauma therapy
Abstract Operation Brain Trauma Therapy (OBTT) is a multicenter pre-clinical drug
screening consortium testing promising therapies for traumatic brain injury (TBI) in three well …
screening consortium testing promising therapies for traumatic brain injury (TBI) in three well …