Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …

Helicases of the superfamily (SF) 1 and 2 are involved in virtually all aspects of RNA and
DNA metabolism. SF1 and SF2 helicases share a catalytic core with high structural …

In the eukaryotic cell, capping of mRNA 5′ ends is an essential structural modification that
allows efficient mRNA translation, directs pre-mRNA splicing and mRNA export from the …

Objectives Infection with yellow fever virus (YFV), the prototypic mosquito-borne flavivirus,
causes severe febrile disease with haemorrhage, multi-organ failure and a high mortality …

The flavivirus NS3 protein is associated with the endoplasmic reticulum membrane via its
close interaction with the central hydrophilic region of the NS2B integral membrane protein …

Dengue is the most prevalent arthropod-borne viral disease worldwide and affects
approximately 2.5 billion people living in over 100 countries. Increasing geographic …

To combat neglected diseases, the Novartis Institute of Tropical Diseases (NITD) was
founded in 2002 through private–public funding from Novartis and the Singapore Economic …

Intracellular RIG-I-like receptors (RLRs, including RIG-I, MDA-5, and LGP2) recognize viral
RNAs as pathogen-associated molecular patterns (PAMPs) and initiate an antiviral immune …

Flaviviridae are small enveloped viruses hosting a positive-sense single-stranded RNA
genome. Besides yellow fever virus, a landmark case in the history of virology, members of …

Dengue is a major global health threat causing 390 million dengue infections and 25,000
deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of …