Ring opening polymerization (ROP) of lactams is a highly efficient and versatile method to
synthesize polyamides. Within the last ten years, significant advances in polymerization …

Cancer is a major health concern worldwide and is still in a continuous surge of seeking for
effective treatments. Since the discovery of RNAi and their mechanism of action, it has …

Abstract Central Nervous System (CNS) diseases, such as Alzheimer's diseases (AD),
Parkinson's Diseases (PD), brain tumors, Huntington's disease (HD), and stroke, still remain …

RNA interference (RNAi) is an efficient strategy to post‐transcriptionally silence gene
expression. While all siRNA drugs on the market target the liver, the lung offers a variety of …

Gene therapy is emerging as a valid method for the treatment of ovarian cancer, including
small interfering RNA (siRNA). Although it is so powerful, few targeting efficient gene …

The blood-brain barrier (BBB) is a highly selective biological barrier that represents a major
bottleneck in the treatment of all types of central nervous system (CNS) disorders. Small …

Polyethylenimine (PEI) is a highly efficient cationic polymer for nucleic acid delivery, and
although it is commonly used in preclinical studies, its clinical application is limited because …

In the field of non-viral drug delivery, polyplexes (PXs) represent an advanced investigated
and highly promising tool for the delivery of nucleic acids. Upon encountering physiological …

In recent decades, biotechnological drugs have emerged as relevant therapeutic tools.
However, therapeutic molecules can exert their activity only if properly formulated and …

Organic nanoparticles are used in nanomedicine, including for cancer treatment and some
types of COVID-19 vaccines. Here, we demonstrate the scalable, rapid, reproducible, and …