N-Acetyl-Aspartyl-Glutamate in Brain Health and Disease

C Morland, K Nordengen - International Journal of Molecular Sciences, 2022 - mdpi.com
N-acetyl-aspartyl-glutamate (NAAG) is the most abundant dipeptide in the brain, where it
acts as a neuromodulator of glutamatergic synapses by activating presynaptic metabotropic …

Green synthesis of CuO nanoparticles for biological applications

B Murugan, MZ Rahman, I Fatimah, JA Lett… - Inorganic Chemistry …, 2023 - Elsevier
The up-to-date growth of nanoscience and nanotechnology has focused on various
applications of metal oxide nanoparticles (NPs) in different fields, such as life sciences …

Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites

A Kaur, W Lin, V Dovhalyuk, L Driutti, ML Di Martino… - Chemical …, 2023 - pubs.rsc.org
Sulfur is an essential element of life. Thiol-containing metabolites in all organisms are
involved in the regulation of diverse biological processes. Especially, the microbiome …

Ergothioneine in the brain

T Ishimoto, Y Kato - FEBS letters, 2022 - Wiley Online Library
Ergothioneine (ERGO) is a naturally occurring food‐derived antioxidant. Despite its
extremely hydrophilic properties, ERGO is easily absorbed from the gastrointestinal tract and …

Gut microbiota in brain tumors: an emerging crucial player

B Lin, Z Ye, Z Ye, M Wang, Z Cao… - CNS Neuroscience & …, 2023 - Wiley Online Library
In recent decades, various roles of the gut microbiota in physiological and pathological
conditions have been uncovered. Among the many interacting pathways between the host …

Antidepression of Xingpijieyu formula targets gut microbiota derived from depressive disorder

Y Li, L Yang, J Li, W Gao, Z Zhao… - CNS neuroscience & …, 2023 - Wiley Online Library
Objective This investigation aims to determine the antidepressant role of Xingpijieyu formula
(XPJYF) mediated via gut microbiota (GM)–brain axis. Methods We collected fecal …

Sleep Promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut Diaphragma juglandis Fructus

J Ji, Y Ye, L Sheng, J Sun, Q Hong, C Liu, J Ding… - Research, 2023 - spj.science.org
Insufficient sleep can produce a multitude of deleterious repercussions on various domains
of human well-being. Concomitantly, the walnut (Juglans mandshurica) confers numerous …

Gut microbiota-associated metabolites and risk of ischemic stroke in REGARDS

Z Ament, A Patki, VM Bhave… - Journal of Cerebral …, 2023 - journals.sagepub.com
Several metabolite markers are independently associated with incident ischemic stroke.
However, prior studies have not accounted for intercorrelated metabolite networks. We used …

Sensitive quantification of short-chain fatty acids combined with global metabolomics in microbiome cultures

W Lin, FR García, EL Norin, D Kart… - Chemical …, 2023 - pubs.rsc.org
The microbiome has been identified to have a key role for the physiology of their human
host. One of the major impacts is the clearance of bacterial pathogens. We have now …

Interventions for non-alcoholic liver disease: A gut microbial metabolites perspective

J Guo, CX Shi, QQ Zhang, W Deng… - Therapeutic …, 2022 - journals.sagepub.com
Over the past two decades, non-alcoholic fatty liver disease (NAFLD) has become a leading
burden of hepatocellular carcinoma and liver transplantation. Although the exact …