MicroRNAs (miRNAs) are approximately 22-nucleotide-long, small non-coding RNAs that
post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple …

Argonaute proteins are highly conserved in almost all organisms. They not only involve in
the biogenesis of small regulatory RNAs, but also regulate gene expression and defend …

Secretion of RNAs in extracellular vesicles is a newly recognized form of intercellular
communication. A potential regulatory protein for microRNA (miRNA) secretion is the critical …

Proximity-dependent biotin labeling (BioID) may identify new targets for cancers driven by
difficult-to-drug oncogenes such as Ras. Therefore, BioID was used with wild-type (WT) and …

Cancer cells bearing distinct KRAS mutations exhibit variable sensitivity to SHP2 inhibitors
(SHP2i). Here we show that cells harboring KRAS Q61H are uniquely resistant to SHP2i …

Regulation of microRNA (miRNA) localization and stability is critical for their extensive
cytoplasmic RNA silencing activity and emerging nuclear functions. Here, we have …

Tight regulation of IL-7Rα expression is essential for normal T-cell development. IL-7Rα gain-
of-function mutations are known drivers of T-cell acute lymphoblastic leukemia (T-ALL) …

In human cancers, oncogenic mutations commonly occur in the RAS genes KRAS, NRAS, or
HRAS, but there are no clinical RAS inhibitors. Mutations are more prevalent in KRAS …

K-Ras frequently acquires gain-of-function mutations (K-Ras G12D being the most common)
that trigger significant transcriptomic and proteomic changes to drive tumorigenesis …

Extensive studies have focused on the misregulation of individual miRNAs in cancer. More
recently, mutations in the miRNA biogenesis and processing machinery have been …