[HTML][HTML] Diagnosis and treatment of NMO spectrum disorder and MOG-encephalomyelitis

N Borisow, M Mori, S Kuwabara, M Scheel… - Frontiers in …, 2018 - frontiersin.org
Neuromyelitis optica spectrum disorders (NMOSD) are autoantibody mediated chronic
inflammatory diseases. Serum antibodies (Abs) against the aquaporin-4 water channel lead …

Leveraging visual outcome measures to advance therapy development in neuroimmunologic disorders

JS Graves, FC Oertel, A Van der Walt… - Neurology …, 2021 - AAN Enterprises
The visual system offers unparalleled precision in the assessment of neuroaxonal damage.
With the majority of patients with multiple sclerosis (MS) experiencing afferent and efferent …

Optical coherence tomography in multiple sclerosis: a 3‐year prospective multicenter study

F Paul, PA Calabresi, F Barkhof… - Annals of clinical …, 2021 - Wiley Online Library
Objective To evaluate changes over 3 years in the thickness of inner retinal layers including
the peripapillary retinal nerve fiber layer (pRNFL), and combined macular ganglion cell and …

Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: an international study

RC Nolan‐Kenney, M Liu, O Akhand… - Annals of …, 2019 - Wiley Online Library
Objective To determine the optimal thresholds for intereye differences in retinal nerve fiber
and ganglion cell+ inner plexiform layer thicknesses for identifying unilateral optic nerve …

Increased serum neurofilament light and thin ganglion cell–inner plexiform layer are additive risk factors for disease activity in early multiple sclerosis

TY Lin, V Vitkova, S Asseyer… - Neurology …, 2021 - AAN Enterprises
Objective To investigate the association of combined serum neurofilament light chain (sNfL)
and retinal optical coherence tomography (OCT) measurements with future disease activity …

Early diagnosis of multiple sclerosis by OCT analysis using Cohen's d method and a neural network as classifier

E Garcia-Martin, M Ortiz, L Boquete… - Computers in Biology …, 2021 - Elsevier
Background The consequences of inflammation, demyelination, axonal degeneration and
neuronal loss in the central nervous system, typical of the development of multiple sclerosis …

Assessments of vessel density and foveal avascular zone metrics in multiple sclerosis: an optical coherence tomography angiography study

H Yilmaz, A Ersoy, E Icel - Eye, 2020 - nature.com
Abstract Background/Objectives To investigate optical coherence tomography angiography
(OCT-A) findings of foveal avascular zone (FAZ) metrics and macular & peripapillary vessel …

Altered fovea in AQP4-IgG–seropositive neuromyelitis optica spectrum disorders

S Motamedi, FC Oertel, SK Yadav… - Neurology …, 2020 - AAN Enterprises
Objective To investigate disease-specific foveal shape changes in patients with
neuromyelitis optica spectrum disorders (NMOSDs) using foveal morphometry. Methods …

[HTML][HTML] Normative data and minimally detectable change for inner retinal layer thicknesses using a semi-automated OCT image segmentation pipeline

S Motamedi, K Gawlik, N Ayadi… - Frontiers in …, 2019 - frontiersin.org
Neurodegenerative and neuroinflammatory diseases regularly cause optic nerve and retinal
damage. Evaluating retinal changes using optical coherence tomography (OCT) in diseases …

Novel uses of retinal imaging with optical coherence tomography in multiple sclerosis

FC Oertel, HG Zimmermann, AU Brandt… - Expert Review of …, 2019 - Taylor & Francis
ABSTRACT Introduction: Multiple Sclerosis (MS) is the most common chronic autoimmune
neuroinflammatory condition in young adults. It is often accompanied by optic neuritis (ON) …