Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of
dramatic feats of regeneration, which have been studied for over 2 centuries. Recent …

In recent years, scientists have made remarkable progress reconstructing the animal
phylogeny. There is broad agreement regarding many deep animal relationships, including …

INTRODUCTION The complete sequence of animal genomes has had a transformative
impact on biological research. Whereas the genome sequence of an organism contains the …

Proliferating cells known as neoblasts include pluripotent stem cells (PSCs) that sustain
tissue homeostasis and regeneration of lost body parts in planarians. However, the lack of …

Planarians are flatworms capable of regenerating any missing body region. This capacity is
mediated by neoblasts, a proliferative cell population that contains pluripotent stem cells …

Cell differentiation is an essential process for the development, growth, reproduction, and
longevity of all multicellular organisms, and its regulation has been the focus of intense …

Planarians are members of the Platyhelminthes (flatworms). These animals have evolved a
remarkable stem cell system. A single pluripotent adult stem cell type (“neoblast”) gives rise …

Planarians can regenerate any missing body part in a process requiring dividing cells called
neoblasts. Historically, neoblasts have largely been considered a homogeneous stem cell …

Abstract Background The freshwater planarian Schmidtea mediterranea has emerged as a
powerful model for studies of regenerative, stem cell, and germ cell biology. Whole-mount in …

Regeneration starts with injury. Yet how injuries affect gene expression in different cell types
and how distinct injuries differ in gene expression remain unclear. We defined the …