Challenges and opportunities in NASH drug development

SA Harrison, AM Allen, J Dubourg, M Noureddin… - Nature medicine, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic
steatohepatitis (NASH), represent a growing worldwide epidemic and a high unmet medical …

the epidemiologic burden of non‐alcoholic fatty liver disease across the world

L Henry, J Paik, ZM Younossi - Alimentary pharmacology & …, 2022 - Wiley Online Library
Background The prevalence of non‐alcoholic fatty liver disease (NAFLD) is increasing in
parallel with obesity and type 2 diabetes. Aim To review the global epidemiology of NAFLD …

MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease

M Eslam, AJ Sanyal, J George, A Sanyal… - Gastroenterology, 2020 - Elsevier
Fatty liver associated with metabolic dysfunction is common, affects a quarter of the
population, and has no approved drug therapy. Although pharmacotherapies are in …

From NAFLD to MAFLD: implications of a premature change in terminology

ZM Younossi, ME Rinella, AJ Sanyal, SA Harrison… - …, 2021 - Wiley Online Library
Despite the substantial gains in our understanding of NAFLD/NASH over the past 2
decades, there has been some dissatisfaction with the terminology “non‐alcoholic” which …

Non-alcoholic fatty liver disease–a global public health perspective

ZM Younossi - Journal of hepatology, 2019 - Elsevier
As the epidemics of obesity and type 2 diabetes mellitus increase worldwide, the prevalence
of non-alcoholic fatty liver disease (NAFLD) is increasing proportionately. The subtype of …

[HTML][HTML] Efficacy and safety of aldafermin, an engineered FGF19 analog, in a randomized, double-blind, placebo-controlled trial of patients with nonalcoholic …

SA Harrison, G Neff, CD Guy, MR Bashir, AH Paredes… - Gastroenterology, 2021 - Elsevier
Background & Aims Aldafermin, an engineered analog of fibroblast growth factor 19, inhibits
bile acid synthesis and regulates metabolic homeostasis. We report results from a 24-week …

Empagliflozin effectively lowers liver fat content in well-controlled type 2 diabetes: a randomized, double-blind, phase 4, placebo-controlled trial

S Kahl, S Gancheva, K Straßburger, C Herder… - Diabetes …, 2020 - Am Diabetes Assoc
OBJECTIVE To evaluate whether the sodium–glucose cotransporter 2 inhibitor
empagliflozin (EMPA) reduces liver fat content (LFC) in recent-onset and metabolically well …

Management of non-alcoholic fatty liver disease

ML Petroni, L Brodosi, E Bugianesi, G Marchesini - Bmj, 2021 - bmj.com
Non-alcoholic fatty liver disease is a very common medical condition, driven by a
combination of genetic and lifestyle factors, ultimately producing a severe chronic liver …

[PDF][PDF] A machine learning approach enables quantitative measurement of liver histology and disease monitoring in NASH

A Taylor‐Weiner, H Pokkalla, L Han, C Jia, R Huss… - …, 2021 - Wiley Online Library
Background and Aims Manual histological assessment is currently the accepted standard for
diagnosing and monitoring disease progression in NASH, but is limited by variability in …

Randomised clinical trial: semaglutide versus placebo reduced liver steatosis but not liver stiffness in subjects with non‐alcoholic fatty liver disease assessed by …

A Flint, G Andersen, P Hockings… - Alimentary …, 2021 - Wiley Online Library
Background Glucagon‐like peptide‐1 receptor agonists may be a treatment option in
patients with non‐alcoholic fatty liver disease (NAFLD). Aims To investigate the effects of …