Connective tissue is one of the four major types of animal tissue and plays essential roles
throughout the human body. Genetic factors, aging, and trauma all contribute to connective …

Hydrogels that provide mechanical support and sustainably release therapeutics have been
used to treat tendon injuries. However, most hydrogels are insufficiently tough, release …

This review highlights recent research on Achilles tendon healing, and comments on the
current clinical controversy surrounding the diagnosis and treatment of injury. The processes …

Key points The amount of fibrotic material in dystrophic mouse muscles relates to contractile
function, but not passive function. Collagen fibres in skeletal muscle are associated with …

Tumors are often characterized by hypoxia, vascular abnormalities, low extracellular pH,
increased interstitial fluid pressure, altered choline-phospholipid metabolism, and aerobic …

Aging is the largest risk factor for Achilles tendon associated disorders and rupture. Although
Achilles tendon macroscale elastic properties are suggested to decline with aging, less is …

Achilles tendon ruptures are common and devastating injuries; however, an optimized
treatment and rehabilitation protocol has yet to be defined. Therefore, the objective of this …

Spontaneous rupture of the Achilles tendon is increasingly common in the middle aged
population. However, the cause for the particularly high incidence of injury in this age group …

The Achilles tendon is the most commonly ruptured tendon in the human body. Numerous
studies have reported incidence of these injuries to be upwards of five times as common in …

Conservative (non‐operative) treatment of Achilles tendon ruptures is a common alternative
to operative treatment. Following rupture, ankle immobilization in plantarflexion is thought to …