Tumour necrosis factor gene polymorphism and disease prevalence

T Qidwai, F Khan - Scandinavian journal of immunology, 2011 - Wiley Online Library
Tumour necrosis factor (TNF), an important proinflammatory cytokine, plays a role in the
regulation of cell differentiation, proliferation and death, as well as in inflammation, innate …

Tumor Necrosis Factor-Alpha G308α Gene Polymorphism and Essential Hypertension: A Meta-Analysis Involving 2244 Participants

Y Li - PLoS One, 2012 - journals.plos.org
Background The tumor necrosis factor-alpha (TNFα) G308A gene polymorphism has been
implicated in susceptibility to essential hypertension (EH), but study results are still …

Polymorphisms in the genes encoding TGF-β1, TNF-α, and IL-6 Show association with Type 1 diabetes mellitus in the Slovak population

J Javor, S Ferencik, M Bucova, M Stuchlikova… - Archivum immunologiae …, 2010 - Springer
Numerous cytokines have been shown to participate in the pathogenesis of type 1 diabetes
(T1D). As gene polymorphisms can influence cytokine production or function, they may …

Association and interaction of the TNF‐alpha gene with other pro‐and anti‐inflammatory cytokine genes and HLA genes in patients with type 1 diabetes from North …

R Kumar, R Goswami, S Agarwal, N Israni… - Tissue …, 2007 - Wiley Online Library
Abstract Type 1 diabetes (T1D) is a multifactorial autoimmune disorder where major
histocompatibility complex (MHC) genes and the insulin‐linked polymorphic region have …

A combination of human leukocyte antigen DQB1* 02 and the tumor necrosis factor α promoter G308A polymorphism predisposes to an insulin-deficient phenotype in …

H Li, L Groop, A Nilsson, J Weng… - The Journal of Clinical …, 2003 - academic.oup.com
Our previous results have suggested that genes outside the human leukocyte antigen (HLA)
class II locus may affect the phenotype of type 2 diabetic patients from families with both type …

Association of tumor necrosis factor‐α ‐308 G/A gene polymorphism with coronary artery diseases: An evidence‐based study

E Kazemi, K Jamialahmadi, A Avan… - Journal of clinical …, 2018 - Wiley Online Library
Background Coronary artery disease (CAD) is the leading cause of death worldwide and
remains a major health problem, providing the rationale for identification of molecular …

Family-based analysis of tumor necrosis factor and lymphotoxin-α tag polymorphisms with type 1 diabetes in the population of South Croatia

V Boraska, E Zeggini, CJ Groves, NW Rayner… - Human immunology, 2009 - Elsevier
Tumor necrosis factor (TNF) and lymphotoxin-α (LTA) are cytokines with a wide range of
inflammatory and immunomodulatory activities. Type 1 diabetes is an autoimmune disease …

Association of TNF promoter polymorphisms with type 1 diabetes in the South Croatian population

V Boraska, V KRABI, V IKE ULI, K Bei… - Biological …, 2008 - SciELO Chile
Type 1 diabetes mellitus (TIDM) is an autoimmune disease characterized by the destruction
of pancreatic p cells. Tumor necrosis factor (TNF) is a pleotropic cytokine with potent …

Tumor Necrosis Factor-α− 308G> A Allelic Variant Modulates Iron Accumulation in Patients with Hereditary Hemochromatosis

PA Krayenbuehl, FE Maly, M Hersberger… - Clinical …, 2006 - academic.oup.com
Background: In vitro and animal studies suggest that tumor necrosis factor α (TNF-α)
modulates intestinal iron transport. We hypothesized that the effect of TNF-α might be …

Absence of association between TNF-α polymorphism and cerebral large-vessel abnormalities in adults with sickle cell anemia

P Vicari, GS Silva, MAE Nogutti, FM Neto… - Acta …, 2011 - karger.com
Stroke is a serious complication of sickle cell anemia (SCA) affecting children and adults.
Recent reports suggested that tumor necrosis factor-α (TNF-α)(–308) polymorphism is an …