[HTML][HTML] Therapeutic vaccines for high-risk HPV-associated diseases
Cancer is the second leading cause of death worldwide, and it is estimated that Human
papillomavirus (HPV) related cancers account for 5% of all human cancers. Current HPV …
papillomavirus (HPV) related cancers account for 5% of all human cancers. Current HPV …
The use of both therapeutic and prophylactic vaccines in the therapy of papillomavirus disease
AR Garbuglia, D Lapa, C Sias… - Frontiers in …, 2020 - frontiersin.org
Human papillomavirus (HPV) is the most common sexually transmitted virus. The high-risk
HPV types (ie, HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59) are considered to be the …
HPV types (ie, HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59) are considered to be the …
Papillomavirus infections—a major cause of human cancers
H Zur Hausen - Biochimica et biophysica acta (BBA)-reviews on cancer, 1996 - Elsevier
The papillomavirus family represents a remarkably heterogeneous group of viruses. At
present, 77 distinct genotypes have been identified in humans and partial sequences have …
present, 77 distinct genotypes have been identified in humans and partial sequences have …
Pathogenesis of human papillomaviruses in differentiating epithelia
MS Longworth, LA Laimins - Microbiology and molecular biology …, 2004 - Am Soc Microbiol
Human papillomaviruses (HPV) are the etiological agents of cervical and other anogenital
malignancies. Over 100 different types of HPVs have been identified to date, and all target …
malignancies. Over 100 different types of HPVs have been identified to date, and all target …
[HTML][HTML] The E1 proteins
M Bergvall, T Melendy, J Archambault - Virology, 2013 - Elsevier
Abstract E1, an ATP-dependent DNA helicase, is the only enzyme encoded by
papillomaviruses (PVs). It is essential for replication and amplification of the viral episome in …
papillomaviruses (PVs). It is essential for replication and amplification of the viral episome in …
Mechanism of DNA translocation in a replicative hexameric helicase
EJ Enemark, L Joshua-Tor - Nature, 2006 - nature.com
The E1 protein of papillomavirus is a hexameric ring helicase belonging to the AAA+ family.
The mechanism that couples the ATP cycle to DNA translocation has been unclear. Here we …
The mechanism that couples the ATP cycle to DNA translocation has been unclear. Here we …
Structure and function of hexameric helicases
SS Patel, KM Picha - Annual review of biochemistry, 2000 - annualreviews.org
▪ Abstract Helicases are motor proteins that couple the hydrolysis of nucleoside triphosphate
(NTPase) to nucleic acid unwinding. The hexameric helicases have a characteristic ring …
(NTPase) to nucleic acid unwinding. The hexameric helicases have a characteristic ring …
Human papillomavirus in cervical and head-and-neck cancer
Cervical cancer is a major cause of cancer mortality in women worldwide and is initiated by
infection with high-risk human papillomaviruses (HPVs). High-risk HPVs, especially HPV-16 …
infection with high-risk human papillomaviruses (HPVs). High-risk HPVs, especially HPV-16 …
Interaction between a geminivirus replication protein and origin DNA is essential for viral replication.
EP Fontes, PA Eagle, PS Sipe, VA Luckow… - Journal of Biological …, 1994 - Elsevier
The geminivirus, tomato golden mosaic virus (TGMV), encodes one protein, AL1, that is
absolutely required for viral DNA replication. AL1 interacts with the TGMV DNA genome by …
absolutely required for viral DNA replication. AL1 interacts with the TGMV DNA genome by …
Human papillomavirus life cycle: active and latent phases
F Stubenrauch, LA Laimins - Seminars in cancer biology, 1999 - Elsevier
Productive infection by human papillomaviruses (HPV) is dependent upon the differentiation
of the host cell. Following entry into basal epithelial cells, HPV genomes are established as …
of the host cell. Following entry into basal epithelial cells, HPV genomes are established as …