Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

Subclinical depressive symptoms are associated with increased risk of Alzheimer's disease
(AD), but the brain mechanisms underlying this relationship are still unclear. We aimed to …

Mild behavioral impairment (MBI) is suggested as risk marker for neurodegenerative
diseases, such as Alzheimer's disease (AD). Recently, pathologic tau deposition in the brain …

Depression and Alzheimer's disease (AD) are substantial public health concerns. In the past
decades, a link between the 2 disease entities has received extensive acknowledgment, yet …

Background Chronic stress and depression are potential risk factors for mild cognitive
impairment and dementia, including Alzheimer disease. The aim was to investigate whether …

Background Major depressive disorder (MDD) is characterized by elevated activity of
peripheral neuro-immune and neuro-oxidative pathways, which may cause neuro-affective …

The earliest abnormality associated with Alzheimer's disease (AD) is the presence of
persistently phosphorylated pretangle tau in locus coeruleus (LC) neurons. LC neuron …

Background Higher neuroticism and lower conscientiousness are risk factors for Alzheimer's
disease and related dementias, but the underlying neuropathological correlates remain …

Abstract Mild Behavioral Impairment (MBI) leverages later-life emergent and persistent
neuropsychiatric symptoms (NPS) to identify a high-risk group for incident dementia …

Introduction We examined baseline differences in depression and antidepressant use
among cognitively normal older adults in five ethnoracial groups and assessed whether …